DBS efficacy in refractory OCD is best when targeting the crossroad between nuc…

{
  "n": 0,
  "doi": "10.2174/1570159x17666190409142555",
  "claim": "DBS efficacy in refractory OCD is best when targeting the crossroad between nucleus accumbens and ventral capsule or the subthalamic nucleus; brain-stimulation studies remain methodologically inconsistent.",
  "cite_key": "Rapinesi2019",
  "evidence": "Systematic review of randomized controlled trials of brain stimulation in OCD across PubMed, Cochrane, Scopus, CINAHL, PsycINFO, Web of Science.",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "Refractory OCD patients across DBS, TMS, tDCS, ECT, VNS systematic review",
  "source_cluster_id": "cluster_13",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Study N Age, Years (Range) Female/ Male (N) Design Observation (Months) DBS Target Results/Conclusions \nMallet et al., 2008 [97] 17 43.05 (29-56) 7/10 Randomized, double-blind, crossover study: two 3-month, and a 1-month washout phases  10 Subthalamic nucleus Active (second) vs. sham (first) stimulation of the subthalamic nucleus: Y-BOCS scores was significantly lower.",
  "replication_evidence_dois": [
    "10.1371/journal.pone.0133591",
    "10.1038/s41380-020-00933-x"
  ],
  "effect_size_source_sentence": "The results of two open studies of VC/VS DBS in OCD patients were in the same direction, with one finding an average 22.2 point drop on the Y-BOCS (60%) after two years in four OCD patients [90] and the other a 12.2 point drop (33%) after 15 months in another four patients [91]."
}

[
  "paper:paper-970adda75256"
]

Study N Age, Years (Range) Female/ Male (N) Design Observation (Months) DBS Target Results/Conclusions Mallet et al., 2008 [97] 17 43.05 (29-56) 7/10 Randomized, double-blind, crossover study: two 3-month, and a 1-month washout phases 10 Subthalamic nucleus Active (second) vs. sham (first) stimulation of the subthalamic nucleus: Y-BOCS scores was significantly lower.

[
  {
    "ref": "paper:paper-970adda75256"
  }
]

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