Version history

{
  "scope": "Refractory OCD patients across DBS, TMS, tDCS, ECT, VNS systematic review",
  "claim_text": "DBS efficacy in refractory OCD is best when targeting the crossroad between nucleus accumbens and ventral capsule or the subthalamic nucleus; brain-stimulation studies remain methodologically inconsistent.",
  "raw_fields": {
    "n": 0,
    "doi": "10.2174/1570159x17666190409142555",
    "claim": "DBS efficacy in refractory OCD is best when targeting the crossroad between nucleus accumbens and ventral capsule or the subthalamic nucleus; brain-stimulation studies remain methodologically inconsistent.",
    "cite_key": "Rapinesi2019",
    "evidence": "Systematic review of randomized controlled trials of brain stimulation in OCD across PubMed, Cochrane, Scopus, CINAHL, PsycINFO, Web of Science.",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "Refractory OCD patients across DBS, TMS, tDCS, ECT, VNS systematic review",
    "source_cluster_id": "cluster_13",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Study N Age, Years (Range) Female/ Male (N) Design Observation (Months) DBS Target Results/Conclusions \nMallet et al., 2008 [97] 17 43.05 (29-56) 7/10 Randomized, double-blind, crossover study: two 3-month, and a 1-month washout phases  10 Subthalamic nucleus Active (second) vs. sham (first) stimulation of the subthalamic nucleus: Y-BOCS scores was significantly lower.",
    "replication_evidence_dois": [
      "10.1371/journal.pone.0133591",
      "10.1038/s41380-020-00933-x"
    ],
    "effect_size_source_sentence": "The results of two open studies of VC/VS DBS in OCD patients were in the same direction, with one finding an average 22.2 point drop on the Y-BOCS (60%) after two years in four OCD patients [90] and the other a 12.2 point drop (33%) after 15 months in another four patients [91]."
  },
  "section_id": "section_14",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-14",
  "source_kind": "review_finding",
  "source_path": "evidence/section_14_evidence_package.json",
  "source_refs": [
    "paper:paper-970adda75256"
  ],
  "source_span": "Study N Age, Years (Range) Female/ Male (N) Design Observation (Months) DBS Target Results/Conclusions Mallet et al., 2008 [97] 17 43.05 (29-56) 7/10 Randomized, double-blind, crossover study: two 3-month, and a 1-month washout phases 10 Subthalamic nucleus Active (second) vs. sham (first) stimulation of the subthalamic nucleus: Y-BOCS scores was significantly lower.",
  "study_system": "Refractory OCD patients across DBS, TMS, tDCS, ECT, VNS systematic review",
  "evidence_refs": [
    {
      "ref": "paper:paper-970adda75256"
    }
  ],
  "section_title": "Loop Dysfunction in Neurological and Psychiatric Disease",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Systematic review of randomized controlled trials of brain stimulation in OCD across PubMed, Cochrane, Scopus, CINAHL, PsycINFO, Web of Science.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-14",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}