Version history

{
  "scope": "mouse whole nervous system; 10x scRNA-seq",
  "claim_text": "Zeisel et al. (2018) profiled the mouse nervous system at single-cell resolution and discovered cell-type organization is governed by three overlapping principles: major class, developmental origin, and neurotransmitter type, with cortical Vip/Sst/Pvalb interneurons defining a major branch of GABAergic CGE/MGE-derived telencephalic interneurons.",
  "raw_fields": {
    "n": 509876,
    "doi": "10.1016/j.cell.2018.06.021",
    "claim": "Zeisel et al. (2018) profiled the mouse nervous system at single-cell resolution and discovered cell-type organization is governed by three overlapping principles: major class, developmental origin, and neurotransmitter type, with cortical Vip/Sst/Pvalb interneurons defining a major branch of GABAergic CGE/MGE-derived telencephalic interneurons.",
    "title": null,
    "cite_key": "Zeisel2018",
    "evidence": "scRNA-seq of 509,876 cells across mouse nervous system; hierarchical taxonomy with cortical interneurons forming distinct subclasses by marker (Vip, Sst, Pvalb) within developmental origin, validating cardinal interneuron classification at whole-nervous-system scale.",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "mouse whole nervous system; 10x scRNA-seq",
    "target_section": "section_02",
    "_source_cluster": "cluster_01_molecular_taxonomy",
    "replication_status": "replicated",
    "_source_cluster_index": 25,
    "claim_source_sentence": "The resulting arrangement of cell types revealed that the mammalian nervous system is organized according to three overlapping and interacting principles: major class (e.g., neurons, astrocytes), developmental origin (e.g., telencephalon, diencephalon, midbrain, hindbrain) and neurotransmitter type."
  },
  "section_id": "section_02",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_02_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-02-classification",
  "source_kind": "review_finding",
  "source_path": "evidence/section_02_evidence_package.json",
  "source_refs": [
    "paper:paper-063a15662345"
  ],
  "source_span": "The resulting arrangement of cell types revealed that the mammalian nervous system is organized according to three overlapping and interacting principles: major class (e.g., neurons, astrocytes), developmental origin (e.g., telencephalon, diencephalon, midbrain, hindbrain) and neurotransmitter type.",
  "study_system": "mouse whole nervous system; 10x scRNA-seq",
  "evidence_refs": [
    {
      "ref": "paper:paper-063a15662345"
    }
  ],
  "section_title": "Molecular Identity and Transcriptomic Taxonomy",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "scRNA-seq of 509,876 cells across mouse nervous system; hierarchical taxonomy with cortical interneurons forming distinct subclasses by marker (Vip, Sst, Pvalb) within developmental origin, validating cardinal interneuron classification at whole-nervous-system scale.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-02-classification",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_02_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}