Zeisel et al. (2018) profiled the mouse nervous system at single-cell resolutio…

Zeisel et al. (2018) profiled the mouse nervous system at single-cell resolution and discovered cell-type organization is governed by three overlapping principles: major class, developmental origin, and neurotransmitter type, with cortical Vip/Sst/Pvalb interneurons defining a major branch of GABAergic CGE/MGE-derived telencephalic interneurons.

{
  "n": 509876,
  "doi": "10.1016/j.cell.2018.06.021",
  "claim": "Zeisel et al. (2018) profiled the mouse nervous system at single-cell resolution and discovered cell-type organization is governed by three overlapping principles: major class, developmental origin, and neurotransmitter type, with cortical Vip/Sst/Pvalb interneurons defining a major branch of GABAergic CGE/MGE-derived telencephalic interneurons.",
  "title": null,
  "cite_key": "Zeisel2018",
  "evidence": "scRNA-seq of 509,876 cells across mouse nervous system; hierarchical taxonomy with cortical interneurons forming distinct subclasses by marker (Vip, Sst, Pvalb) within developmental origin, validating cardinal interneuron classification at whole-nervous-system scale.",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "mouse whole nervous system; 10x scRNA-seq",
  "target_section": "section_02",
  "_source_cluster": "cluster_01_molecular_taxonomy",
  "replication_status": "replicated",
  "_source_cluster_index": 25,
  "claim_source_sentence": "The resulting arrangement of cell types revealed that the mammalian nervous system is organized according to three overlapping and interacting principles: major class (e.g., neurons, astrocytes), developmental origin (e.g., telencephalon, diencephalon, midbrain, hindbrain) and neurotransmitter type."
}

[
  "paper:paper-063a15662345"
]

The resulting arrangement of cell types revealed that the mammalian nervous system is organized according to three overlapping and interacting principles: major class (e.g., neurons, astrocytes), developmental origin (e.g., telencephalon, diencephalon, midbrain, hindbrain) and neurotransmitter type.

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scRNA-seq of 509,876 cells across mouse nervous system; hierarchical taxonomy with cortical interneurons forming distinct subclasses by marker (Vip, Sst, Pvalb) within developmental origin, validating cardinal interneuron classification at whole-nervous-system scale.