Whole-brain mapping shows asymmetric monosynaptic excitatory inputs to D1-SPNs…

Details

scope: mouse
claim_text: Whole-brain mapping shows asymmetric monosynaptic excitatory inputs to D1-SPNs and D2-SPNs whose functional consequence is preferential D1-SPN activation of the direct pathway and broader D2-SPN engagement of both pathways.
section_id: section_04
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json
effect_size
review_repo: ComputationalReviewLoops
section_ref: wiki_page:computationalreviewloops-04
source_kind: review_finding
source_path: evidence/section_04_evidence_package.json
source_span: These results are consistent with the functional connectivity in which the excitatory inputs to D1-SPNs mostly drive the direct pathway, and the inputs to D2-SPNs target both the indirect and direct pathways ( Figure 3A ).
study_system: mouse
section_title: Striatal Output Pathways: Direct, Indirect, and Beyond
evidence_summary: Asymmetric cortical projections to striatal direct and indirect pathways distinctly control actions.
review_bundle_ref: analysis_bundle:ab-d49e54403ef9
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-d49e54403ef9
source_artifact_ref: wiki_page:computationalreviewloops-04
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json
commit_sha: 0632aae8abc141909207fe91f6349b9e36489c3b
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.7554/elife.92992",
  "claim": "Whole-brain mapping shows asymmetric monosynaptic excitatory inputs to D1-SPNs and D2-SPNs whose functional consequence is preferential D1-SPN activation of the direct pathway and broader D2-SPN engagement of both pathways.",
  "cite_key": "Klug2025",
  "evidence": "Asymmetric cortical projections to striatal direct and indirect pathways distinctly control actions.",
  "effect_size": "",
  "text_access": "fulltext",
  "study_system": "mouse",
  "source_cluster_id": "cluster_04",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "These results are consistent with the functional connectivity in which the excitatory inputs to D1-SPNs mostly drive the direct pathway, and the inputs to D2-SPNs target both the indirect and direct pathways ( Figure 3A ).",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

source_refs

[
  "paper:paper-047f747899b8"
]

evidence_refs

[
  {
    "ref": "paper:paper-047f747899b8"
  }
]

source_policy

{
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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}

Whole-brain mapping shows asymmetric monosynaptic excitatory inputs to D1-SPNs…

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Replication

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