Cre-targeted G-deleted rabies tracing reveals asymmetric overlap between cortic…

Cre-targeted G-deleted rabies tracing reveals asymmetric overlap between cortical inputs to D1- and D2-SPNs: more than two-thirds of excitatory inputs to D2-SPNs also target D1-SPNs while only about one-third do so in the reverse direction, and pathway-specific corticostriatal projection optogenetic activation produces dissociable effects on locomotion, reinforcement learning and sequence behavior.

{
  "n": 7,
  "doi": "10.7554/elife.92992",
  "claim": "Cre-targeted G-deleted rabies tracing reveals asymmetric overlap between cortical inputs to D1- and D2-SPNs: more than two-thirds of excitatory inputs to D2-SPNs also target D1-SPNs while only about one-third do so in the reverse direction, and pathway-specific corticostriatal projection optogenetic activation produces dissociable effects on locomotion, reinforcement learning and sequence behavior.",
  "cite_key": "Klug2025",
  "evidence": "",
  "effect_size": ">2/3 of D2-SPN inputs are also D1-SPN inputs vs 1/3 reverse",
  "text_access": "fulltext",
  "study_system": "mouse cortico-striatal D1-Cre / D2-Cre",
  "source_cluster_id": "cluster_10",
  "replication_status": "contested",
  "claim_source_sentence": "Here using a G-deleted rabies system in mice, we found that more than two-thirds of excitatory inputs to D2-SPNs also target D1-SPNs, while only one-third do so vice versa.",
  "replication_evidence_dois": [
    "10.1016/j.neuron.2013.05.014"
  ],
  "effect_size_source_sentence": "Here using a G-deleted rabies system in mice, we found that more than two-thirds of excitatory inputs to D2-SPNs also target D1-SPNs, while only one-third do so vice versa."
}

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]

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