Details
- scope
- Mouse barrel cortex L4→L2/3 and L2/3→L2/3 synapses (slice)
- claim_text
- At mouse barrel-cortex L4→L2/3 synapses, t-LTP and t-LTD show a double dissociation by NMDAR subunit: a GluN2A-preferring antagonist blocks t-LTP but not t-LTD, while a GluN2C/D antagonist blocks t-LTD but not t-LTP.
- section_id
- section_12
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_12_evidence_package.json
- review_repo
- ComputationalReviewRecurrence
- section_ref
- wiki_page:computationalreviewrecurrence-12-plasticity
- source_kind
- review_finding
- source_path
- evidence/section_12_evidence_package.json
- source_span
- An antagonist at GluN2C/D subunit-containing NMDA receptors blocked t-LTD but not t-LTP. Conversely, a GluN2A subunit-preferring antagonist blocked t-LTP but not t-LTD.
- study_system
- Mouse barrel cortex L4→L2/3 and L2/3→L2/3 synapses (slice)
- section_title
- 12. Plasticity at E→E synapses in mouse — Hebbian, STDP, behavioural-time-scale plasticity; how plasticity shapes the recurrent matrix during learning
- evidence_summary
- Subunit-preferring antagonists dissociated t-LTP and t-LTD at L4→L2/3 synapses; the GluN2C/D requirement for t-LTD was synapse-specific (not present at horizontal L2/3→L2/3 t-LTD, which was GluN2B-dependent).
- review_bundle_ref
- analysis_bundle:ab-d9c479db9be9
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-d9c479db9be9
- source_artifact_ref
- wiki_page:computationalreviewrecurrence-12-plasticity
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_12_evidence_package.json
- commit_sha
- 79ce062d54a924ce05953ec90aa9d26044d2b48f
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1093/cercor/bhp067", "claim": "At mouse barrel-cortex L4→L2/3 synapses, t-LTP and t-LTD show a double dissociation by NMDAR subunit: a GluN2A-preferring antagonist blocks t-LTP but not t-LTD, while a GluN2C/D antagonist blocks t-LTD but not t-LTP.", "cite_key": "Banerjee2009", "evidence": "Subunit-preferring antagonists dissociated t-LTP and t-LTD at L4→L2/3 synapses; the GluN2C/D requirement for t-LTD was synapse-specific (not present at horizontal L2/3→L2/3 t-LTD, which was GluN2B-dependent).", "effect_size": null, "text_access": "abstract_only", "study_system": "Mouse barrel cortex L4→L2/3 and L2/3→L2/3 synapses (slice)", "argument_role": "supporting", "replication_status": "replication_unknown", "claim_source_sentence": "An antagonist at GluN2C/D subunit-containing NMDA receptors blocked t-LTD but not t-LTP. Conversely, a GluN2A subunit-preferring antagonist blocked t-LTP but not t-LTD.", "source_provenance_status": "non_substring_match", "replication_evidence_dois": [], "effect_size_source_sentence": null }- source_refs
[ "paper:paper-673cb5de6c80" ]
- evidence_refs
[ { "ref": "paper:paper-673cb5de6c80" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }