Version history

{
  "scope": "mouse, primary somatosensory cortex (P30)",
  "claim_text": "PROX1 is expressed in 84% of LGE/CGE/POA-derived cortical interneurons and labels nearly all CGE-lineage cortical interneuron subtypes including 100% of VIP-expressing cells.",
  "raw_fields": {
    "n": 3,
    "doi": "10.1371/journal.pone.0077339",
    "claim": "PROX1 is expressed in 84% of LGE/CGE/POA-derived cortical interneurons and labels nearly all CGE-lineage cortical interneuron subtypes including 100% of VIP-expressing cells.",
    "title": null,
    "cite_key": "Rubin2013",
    "evidence": "Body section, Results: shown by genetic lineage tracing using Lhx6-Cre;Dlx1-Venus and Nkx5.1-Cre;R26R-YFP; quantification carried out in primary somatosensory cortex of P30 mice.",
    "effect_size": "84% of LGE/CGE/POA-derived interneurons PROX1+; 100% of VIP-expressing population PROX1+",
    "figure_data": [
      {
        "type": "marker_quantification",
        "unit": "percent",
        "value": 84,
        "metric": "% PROX1+ within fate-mapped CGE/LGE/POA-derived interneurons (P30 mouse S1)",
        "source": "Fig. 3C",
        "context": "PROX1 IHC overlap with Lhx6-Cre;Dlx1-Venus AND Nkx5.1-Cre;R26R-YFP fate-mapped subpopulation"
      },
      {
        "type": "marker_quantification",
        "unit": "percent",
        "value": 100,
        "metric": "% PROX1+ within VIP+ neocortical interneurons",
        "source": "Fig. 4A,B",
        "context": "All VIP-expressing cortical cells co-express PROX1"
      }
    ],
    "text_access": "fulltext",
    "study_system": "mouse, primary somatosensory cortex (P30)",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "replicated",
    "_source_cluster_index": 0,
    "claim_source_sentence": "Results: PROX1 Identifies CR- NPY- RLN- and VIP-expressing Interneurons in the Adult Cortex Data so far showed that PROX1 is expressed in 84% of all LGE/CGE/POA-derived cortical interneurons ( Fig. 3C ).",
    "replication_evidence_dois": [
      "10.1523/jneurosci.1164-15.2015",
      "10.1523/jneurosci.1021-21.2021"
    ],
    "effect_size_source_sentence": "PROX1 was found to be expressed in large numbers of calretinin (CR)-, neuropeptide Y (NPY)- and RLN-positive cells as well as in 100% of the VIP-expressing population ( Fig. 4A,B )."
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": "84% of LGE/CGE/POA-derived interneurons PROX1+; 100% of VIP-expressing population PROX1+",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-d0d958f4bbd9"
  ],
  "source_span": "Results: PROX1 Identifies CR- NPY- RLN- and VIP-expressing Interneurons in the Adult Cortex Data so far showed that PROX1 is expressed in 84% of all LGE/CGE/POA-derived cortical interneurons ( Fig. 3C ).",
  "study_system": "mouse, primary somatosensory cortex (P30)",
  "evidence_refs": [
    {
      "ref": "paper:paper-d0d958f4bbd9"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Body section, Results: shown by genetic lineage tracing using Lhx6-Cre;Dlx1-Venus and Nkx5.1-Cre;R26R-YFP; quantification carried out in primary somatosensory cortex of P30 mice.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}