PROX1 is expressed in 84% of LGE/CGE/POA-derived cortical interneurons and labe…

{
  "n": 3,
  "doi": "10.1371/journal.pone.0077339",
  "claim": "PROX1 is expressed in 84% of LGE/CGE/POA-derived cortical interneurons and labels nearly all CGE-lineage cortical interneuron subtypes including 100% of VIP-expressing cells.",
  "title": null,
  "cite_key": "Rubin2013",
  "evidence": "Body section, Results: shown by genetic lineage tracing using Lhx6-Cre;Dlx1-Venus and Nkx5.1-Cre;R26R-YFP; quantification carried out in primary somatosensory cortex of P30 mice.",
  "effect_size": "84% of LGE/CGE/POA-derived interneurons PROX1+; 100% of VIP-expressing population PROX1+",
  "figure_data": [
    {
      "type": "marker_quantification",
      "unit": "percent",
      "value": 84,
      "metric": "% PROX1+ within fate-mapped CGE/LGE/POA-derived interneurons (P30 mouse S1)",
      "source": "Fig. 3C",
      "context": "PROX1 IHC overlap with Lhx6-Cre;Dlx1-Venus AND Nkx5.1-Cre;R26R-YFP fate-mapped subpopulation"
    },
    {
      "type": "marker_quantification",
      "unit": "percent",
      "value": 100,
      "metric": "% PROX1+ within VIP+ neocortical interneurons",
      "source": "Fig. 4A,B",
      "context": "All VIP-expressing cortical cells co-express PROX1"
    }
  ],
  "text_access": "fulltext",
  "study_system": "mouse, primary somatosensory cortex (P30)",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "replicated",
  "_source_cluster_index": 0,
  "claim_source_sentence": "Results: PROX1 Identifies CR- NPY- RLN- and VIP-expressing Interneurons in the Adult Cortex Data so far showed that PROX1 is expressed in 84% of all LGE/CGE/POA-derived cortical interneurons ( Fig. 3C ).",
  "replication_evidence_dois": [
    "10.1523/jneurosci.1164-15.2015",
    "10.1523/jneurosci.1021-21.2021"
  ],
  "effect_size_source_sentence": "PROX1 was found to be expressed in large numbers of calretinin (CR)-, neuropeptide Y (NPY)- and RLN-positive cells as well as in 100% of the VIP-expressing population ( Fig. 4A,B )."
}

[
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]

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    "Local review repositories are read-only inputs.",
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