In the mouse ganglionic eminence, MEIS2 binds projection-neuron-specific enhanc…

In the mouse ganglionic eminence, MEIS2 binds projection-neuron-specific enhancers and drives GABAergic projection-neuron (e.g. striatal SPN) fate; MEIS2 requires DLX5 to occupy correct sites. In interneuron precursors, LHX6 represses MEIS2–DLX5 activation of projection-neuron enhancers, redirecting fate toward MGE-cortical interneuron lineages — establishing a 'differential binding' model for projection-neuron vs interneuron fate choice.

{
  "n": null,
  "doi": "10.1038/s41593-024-01611-9",
  "claim": "In the mouse ganglionic eminence, MEIS2 binds projection-neuron-specific enhancers and drives GABAergic projection-neuron (e.g. striatal SPN) fate; MEIS2 requires DLX5 to occupy correct sites. In interneuron precursors, LHX6 represses MEIS2–DLX5 activation of projection-neuron enhancers, redirecting fate toward MGE-cortical interneuron lineages — establishing a 'differential binding' model for projection-neuron vs interneuron fate choice.",
  "title": null,
  "cite_key": "Dvoretskova2024",
  "evidence": "Nat Neurosci 2024. Method: in vivo CRISPR, lineage tracing, ChIP-seq in mouse embryonic GE.",
  "effect_size": null,
  "figure_data": null,
  "text_access": "abstract_only",
  "key_entities": [
    "MEIS2",
    "DLX5",
    "LHX6",
    "projection neuron",
    "interneuron",
    "enhancer",
    "ChIP-seq",
    "CRISPR",
    "ganglionic eminence",
    "fate specification"
  ],
  "study_system": "mouse embryonic ganglionic eminence",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "single_study",
  "_source_cluster_index": 142,
  "claim_source_sentence": "We use a combination of in vivo CRISPR perturbation, lineage tracing and ChIP-sequencing analyses and show that the transcription factor MEIS2 favors the development of projection neurons by binding enhancer regions in projection-neuron-specific genes during mouse embryonic development. MEIS2 requires the presence of the homeodomain transcription factor DLX5 to direct its functional activity toward the appropriate binding sites. In interneuron precursors, the transcription factor LHX6 represses the MEIS2-DLX5-dependent activation of projection-neuron-specific enhancers.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

[
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]

We use a combination of in vivo CRISPR perturbation, lineage tracing and ChIP-sequencing analyses and show that the transcription factor MEIS2 favors the development of projection neurons by binding enhancer regions in projection-neuron-specific genes during mouse embryonic development. MEIS2 requires the presence of the homeodomain transcription factor DLX5 to direct its functional activity toward the appropriate b...

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