Version history

{
  "scope": "Treatment-refractory OCD patients across multiple DBS trials (RCTs and cohorts)",
  "claim_text": "Two blinded RCTs of DBS for refractory OCD report 37% (level I) and 25% (level II) Y-BOCS improvement; cohort and prospective multi-center studies report 40% and 42% improvement, but ventral-anterior-capsule DBS for OCD is classified as emerging, not yet established therapy.",
  "raw_fields": {
    "n": 70,
    "doi": "10.1038/s41380-020-00933-x",
    "claim": "Two blinded RCTs of DBS for refractory OCD report 37% (level I) and 25% (level II) Y-BOCS improvement; cohort and prospective multi-center studies report 40% and 42% improvement, but ventral-anterior-capsule DBS for OCD is classified as emerging, not yet established therapy.",
    "cite_key": "Wu2020",
    "evidence": "Consensus review using WSSFN criteria (≥2 blinded RCTs from different groups in same target/indication) for treatment-refractory OCD DBS.",
    "effect_size": "RCTs: 37% and 25% Y-BOCS reduction; cohort 40%; multicenter 42%",
    "text_access": "fulltext",
    "study_system": "Treatment-refractory OCD patients across multiple DBS trials (RCTs and cohorts)",
    "source_cluster_id": "cluster_13",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Conclusion\nThe Task Force on Neurosurgery for Psychiatric Disorders\nof the WSSFN accepts that electrical stimulation for\notherwise treatment refractory obsessive-compulsive dis-\norder using a multipolar electrode implanted in the region\nof the bed nucleus of the stria terminalis and/or anterior\nlimb of the internal capsule represents an emerging\ntherapy.",
    "replication_evidence_dois": [
      "10.1371/journal.pone.0133591",
      "10.2174/1570159x17666190409142555"
    ],
    "effect_size_source_sentence": "In summary, a signi ficant albeit less than optimal\neffect was observed in the active stimulation phase (25% vs.\nthe required 35%)."
  },
  "section_id": "section_14",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json",
  "effect_size": "RCTs: 37% and 25% Y-BOCS reduction; cohort 40%; multicenter 42%",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-14",
  "source_kind": "review_finding",
  "source_path": "evidence/section_14_evidence_package.json",
  "source_refs": [
    "paper:paper-192e8d1eb066"
  ],
  "source_span": "Conclusion The Task Force on Neurosurgery for Psychiatric Disorders of the WSSFN accepts that electrical stimulation for otherwise treatment refractory obsessive-compulsive dis- order using a multipolar electrode implanted in the region of the bed nucleus of the stria terminalis and/or anterior limb of the internal capsule represents an emerging therapy.",
  "study_system": "Treatment-refractory OCD patients across multiple DBS trials (RCTs and cohorts)",
  "evidence_refs": [
    {
      "ref": "paper:paper-192e8d1eb066"
    }
  ],
  "section_title": "Loop Dysfunction in Neurological and Psychiatric Disease",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Consensus review using WSSFN criteria (≥2 blinded RCTs from different groups in same target/indication) for treatment-refractory OCD DBS.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-14",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}