Two blinded RCTs of DBS for refractory OCD report 37% (level I) and 25% (level…

Two blinded RCTs of DBS for refractory OCD report 37% (level I) and 25% (level II) Y-BOCS improvement; cohort and prospective multi-center studies report 40% and 42% improvement, but ventral-anterior-capsule DBS for OCD is classified as emerging, not yet established therapy.

{
  "n": 70,
  "doi": "10.1038/s41380-020-00933-x",
  "claim": "Two blinded RCTs of DBS for refractory OCD report 37% (level I) and 25% (level II) Y-BOCS improvement; cohort and prospective multi-center studies report 40% and 42% improvement, but ventral-anterior-capsule DBS for OCD is classified as emerging, not yet established therapy.",
  "cite_key": "Wu2020",
  "evidence": "Consensus review using WSSFN criteria (≥2 blinded RCTs from different groups in same target/indication) for treatment-refractory OCD DBS.",
  "effect_size": "RCTs: 37% and 25% Y-BOCS reduction; cohort 40%; multicenter 42%",
  "text_access": "fulltext",
  "study_system": "Treatment-refractory OCD patients across multiple DBS trials (RCTs and cohorts)",
  "source_cluster_id": "cluster_13",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Conclusion\nThe Task Force on Neurosurgery for Psychiatric Disorders\nof the WSSFN accepts that electrical stimulation for\notherwise treatment refractory obsessive-compulsive dis-\norder using a multipolar electrode implanted in the region\nof the bed nucleus of the stria terminalis and/or anterior\nlimb of the internal capsule represents an emerging\ntherapy.",
  "replication_evidence_dois": [
    "10.1371/journal.pone.0133591",
    "10.2174/1570159x17666190409142555"
  ],
  "effect_size_source_sentence": "In summary, a signi ficant albeit less than optimal\neffect was observed in the active stimulation phase (25% vs.\nthe required 35%)."
}

[
  "paper:paper-192e8d1eb066"
]

Conclusion The Task Force on Neurosurgery for Psychiatric Disorders of the WSSFN accepts that electrical stimulation for otherwise treatment refractory obsessive-compulsive dis- order using a multipolar electrode implanted in the region of the bed nucleus of the stria terminalis and/or anterior limb of the internal capsule represents an emerging therapy.

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