Presynaptic muscarinic acetylcholine receptor activation reduces IPSC amplitude…

Details

scope: mouse CA1 hippocampus, PV-GFP mice, juvenile
claim_text: Presynaptic muscarinic acetylcholine receptor activation reduces IPSC amplitude and transiently reduces paired-pulse depression at PV BC synapses
section_id: section_06_evidence_package
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_06_evidence_package.json
effect_size: pr reduced twofold, Ca2+ transient reduced fourfold
review_repo: ComputationalReviewPV
section_ref: wiki_page:computationalreviewpv-06
source_kind: review_finding
source_path: evidence/section_06_evidence_package.json
source_span: mAChR activation reduced IPSC amplitude and transiently reduced PPD, but MPD was largely maintained.
study_system: mouse CA1 hippocampus, PV-GFP mice, juvenile
section_title: Synaptic Physiology: Input Specificity, Output Targeting, and Short-Term Dynamics
evidence_summary: Muscarine (10 μM) reduced initial release probability twofold and presynaptic calcium transient fourfold, but slowed calcium-dependent recovery, preserving depression during sustained activity
review_bundle_ref: analysis_bundle:ab-e6261c8263e7
replication_status: independently_replicated
review_package_ref: analysis_bundle:ab-e6261c8263e7
source_artifact_ref: wiki_page:computationalreviewpv-06
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_06_evidence_package.json
commit_sha: df9fc7e8d455b084152c9d713558dae0013cef21
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1152/jn.00167.2014",
  "claim": "Presynaptic muscarinic acetylcholine receptor activation reduces IPSC amplitude and transiently reduces paired-pulse depression at PV BC synapses",
  "evidence": "Muscarine (10 μM) reduced initial release probability twofold and presynaptic calcium transient fourfold, but slowed calcium-dependent recovery, preserving depression during sustained activity",
  "effect_size": "pr reduced twofold, Ca2+ transient reduced fourfold",
  "text_access": "abstract_only",
  "study_system": "mouse CA1 hippocampus, PV-GFP mice, juvenile",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "mAChR activation reduced IPSC amplitude and transiently reduced PPD, but MPD was largely maintained.",
  "replication_evidence_dois": [
    "10.1111/j.1460-9568.2010.07292.x",
    "10.1007/s00429-017-1427-x"
  ],
  "effect_size_source_sentence": "mAChR activation reduced the presynaptic calcium transient fourfold and initial pr twofold, thereby reducing PPD."
}

source_refs

[
  "paper:paper-7546e7b4175f"
]

evidence_refs

[
  {
    "ref": "paper:paper-7546e7b4175f"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

Presynaptic muscarinic acetylcholine receptor activation reduces IPSC amplitude…

Details

Replication

Discussion