Version history

{
  "scope": "mouse CA1 hippocampus, PV-GFP mice, juvenile",
  "claim_text": "Presynaptic muscarinic acetylcholine receptor activation reduces IPSC amplitude and transiently reduces paired-pulse depression at PV BC synapses",
  "raw_fields": {
    "n": 0,
    "doi": "10.1152/jn.00167.2014",
    "claim": "Presynaptic muscarinic acetylcholine receptor activation reduces IPSC amplitude and transiently reduces paired-pulse depression at PV BC synapses",
    "evidence": "Muscarine (10 μM) reduced initial release probability twofold and presynaptic calcium transient fourfold, but slowed calcium-dependent recovery, preserving depression during sustained activity",
    "effect_size": "pr reduced twofold, Ca2+ transient reduced fourfold",
    "text_access": "abstract_only",
    "study_system": "mouse CA1 hippocampus, PV-GFP mice, juvenile",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "mAChR activation reduced IPSC amplitude and transiently reduced PPD, but MPD was largely maintained.",
    "replication_evidence_dois": [
      "10.1111/j.1460-9568.2010.07292.x",
      "10.1007/s00429-017-1427-x"
    ],
    "effect_size_source_sentence": "mAChR activation reduced the presynaptic calcium transient fourfold and initial pr twofold, thereby reducing PPD."
  },
  "section_id": "section_06_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_06_evidence_package.json",
  "effect_size": "pr reduced twofold, Ca2+ transient reduced fourfold",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-06",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-7546e7b4175f"
  ],
  "source_span": "mAChR activation reduced IPSC amplitude and transiently reduced PPD, but MPD was largely maintained.",
  "study_system": "mouse CA1 hippocampus, PV-GFP mice, juvenile",
  "evidence_refs": [
    {
      "ref": "paper:paper-7546e7b4175f"
    }
  ],
  "section_title": "Synaptic Physiology: Input Specificity, Output Targeting, and Short-Term Dynamics",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Muscarine (10 μM) reduced initial release probability twofold and presynaptic calcium transient fourfold, but slowed calcium-dependent recovery, preserving depression during sustained activity",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-06",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_06_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}