Version history

{
  "scope": "Freely moving mouse cortex (S1, V1, cerebellar), fiber-bundle 2P microscope",
  "claim_text": "2P-FENDO-II is a fiber-bundle two-photon microscope that delivers concurrent two-photon calcium imaging and holographic optogenetic photostimulation across a four-times-larger field of view than its predecessor in freely moving mice — demonstrated across somatosensory, visual, and cerebellar cortex with jGCaMP7s and ChRmine.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.crmeth.2026.101305",
    "claim": "2P-FENDO-II is a fiber-bundle two-photon microscope that delivers concurrent two-photon calcium imaging and holographic optogenetic photostimulation across a four-times-larger field of view than its predecessor in freely moving mice — demonstrated across somatosensory, visual, and cerebellar cortex with jGCaMP7s and ChRmine.",
    "cite_key": "Blot2026",
    "evidence": "Concurrent 2P imaging + holographic stim through fiber bundle in freely moving mice; demonstrated in three cortical regions.",
    "effect_size": "4× larger field of view vs. 2P-FENDO-I; concurrent imaging + holographic stim",
    "text_access": "fulltext",
    "study_system": "Freely moving mouse cortex (S1, V1, cerebellar), fiber-bundle 2P microscope",
    "argument_role": "supporting",
    "replication_status": "instrument-paper",
    "claim_source_sentence": "Here, we present a significantly optimized 2P-FENDO-II system that achieves a four-times-larger field of view and a more homogeneous light distribution across the field of view, both for imaging and photostimulation, while achieving better flexibility and thus optimal adaptation to the study of freely moving mice.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "2P-FENDO-II system that achieves a four-times-larger field of view and a more homogeneous light distribution across the field of view"
  },
  "section_id": "section_15",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_15_evidence_package.json",
  "effect_size": "4× larger field of view vs. 2P-FENDO-I; concurrent imaging + holographic stim",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-15-methods-limits",
  "source_kind": "review_finding",
  "source_path": "evidence/section_15_evidence_package.json",
  "source_refs": [
    "paper:paper-f5305ecce616"
  ],
  "source_span": "Here, we present a significantly optimized 2P-FENDO-II system that achieves a four-times-larger field of view and a more homogeneous light distribution across the field of view, both for imaging and photostimulation, while achieving better flexibility and thus optimal adaptation to the study of freely moving mice.",
  "study_system": "Freely moving mouse cortex (S1, V1, cerebellar), fiber-bundle 2P microscope",
  "evidence_refs": [
    {
      "ref": "paper:paper-f5305ecce616"
    }
  ],
  "section_title": "15. Methodological limits and emerging tools — what current mouse-cortex tools cannot yet measure about E→E recurrence (subthreshold network activity, fast plasticity in vivo, millimetre-scale dynamic connectomes), and what is on the near horizon",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
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  "evidence_summary": "Concurrent 2P imaging + holographic stim through fiber bundle in freely moving mice; demonstrated in three cortical regions.",
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  "replication_status": "instrument-paper",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-15-methods-limits",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_15_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}