Version history

{
  "scope": "mouse PFC→HC",
  "claim_text": "PFC sends monosynaptic long-range GABAergic projections to hippocampus that preferentially inhibit VIP+ interneurons, suppressing the local VIP→SST disinhibitory motif and increasing hippocampal feedforward inhibition; this projection is required for object-location encoding and exploratory behavior.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.cell.2022.04.001",
    "claim": "PFC sends monosynaptic long-range GABAergic projections to hippocampus that preferentially inhibit VIP+ interneurons, suppressing the local VIP→SST disinhibitory motif and increasing hippocampal feedforward inhibition; this projection is required for object-location encoding and exploratory behavior.",
    "title": null,
    "cite_key": "Malik2022",
    "evidence": "Optogenetic activation of PFC GABAergic terminals in hippocampus + paired in vivo and slice recordings; behavioral assays.",
    "effect_size": "Cell-type-specific PFC long-range inhibitory projection to VIP+ HC interneurons.",
    "text_access": "fulltext",
    "study_system": "mouse PFC→HC",
    "_source_cluster": "cluster_05_synaptic_connectivity",
    "replication_status": "single-study",
    "_source_cluster_index": 25,
    "claim_source_sentence": "Here we describe monosynaptic long-range GABAergic projections from PFC to hippocampus. These preferentially inhibit vasoactive intestinal polypeptide-expressing interneurons, which are known to disinhibit hippocampal microcircuits.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "effect_size": "Cell-type-specific PFC long-range inhibitory projection to VIP+ HC interneurons.",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-f83cd6e11b6c"
  ],
  "source_span": "Here we describe monosynaptic long-range GABAergic projections from PFC to hippocampus. These preferentially inhibit vasoactive intestinal polypeptide-expressing interneurons, which are known to disinhibit hippocampal microcircuits.",
  "study_system": "mouse PFC→HC",
  "evidence_refs": [
    {
      "ref": "paper:paper-f83cd6e11b6c"
    }
  ],
  "section_title": "Synaptic Properties and Connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Optogenetic activation of PFC GABAergic terminals in hippocampus + paired in vivo and slice recordings; behavioral assays.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}