- claim_text
PFC sends monosynaptic long-range GABAergic projections to hippocampus that preferentially inhibit VIP+ interneurons, suppressing the local VIP→SST disinhibitory motif and increasing hippocampal feedforward inhibition; this projection is required for object-location encoding and exploratory behavior.
- raw_fields
{
"n": null,
"doi": "10.1016/j.cell.2022.04.001",
"claim": "PFC sends monosynaptic long-range GABAergic projections to hippocampus that preferentially inhibit VIP+ interneurons, suppressing the local VIP→SST disinhibitory motif and increasing hippocampal feedforward inhibition; this projection is required for object-location encoding and exploratory behavior.",
"title": null,
"cite_key": "Malik2022",
"evidence": "Optogenetic activation of PFC GABAergic terminals in hippocampus + paired in vivo and slice recordings; behavioral assays.",
"effect_size": "Cell-type-specific PFC long-range inhibitory projection to VIP+ HC interneurons.",
"text_access": "fulltext",
"study_system": "mouse PFC→HC",
"_source_cluster": "cluster_05_synaptic_connectivity",
"replication_status": "single-study",
"_source_cluster_index": 25,
"claim_source_sentence": "Here we describe monosynaptic long-range GABAergic projections from PFC to hippocampus. These preferentially inhibit vasoactive intestinal polypeptide-expressing interneurons, which are known to disinhibit hippocampal microcircuits.",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-f83cd6e11b6c"
]
- evidence_refs
[
{
"ref": "paper:paper-f83cd6e11b6c"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}