In mouse V1, L5 pyramidal neurons — the only neocortical cell type whose dendri…

In mouse V1, L5 pyramidal neurons — the only neocortical cell type whose dendrites span all six cortical layers — display active dendritic properties enabling coincidence detection between basal (intracolumnar) and apical-tuft (L1) translaminar inputs, with the basal-tuft coincidence controlling somatic burst output and contributing to orientation tuning.

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  "n": 0,
  "doi": "10.1371/journal.pcbi.1004090",
  "claim": "In mouse V1, L5 pyramidal neurons — the only neocortical cell type whose dendrites span all six cortical layers — display active dendritic properties enabling coincidence detection between basal (intracolumnar) and apical-tuft (L1) translaminar inputs, with the basal-tuft coincidence controlling somatic burst output and contributing to orientation tuning.",
  "cite_key": "Shai2015",
  "evidence": "Patch-clamp recordings from L5 pyramidal neurons in mouse V1 slices to measure active dendritic properties; multi-compartmental computational model parameterized to recordings; simulation of orientation tuning.",
  "effect_size": "Coincidence-detection regime supported by experimentally measured Ca2+/Na+ active dendritic properties; sigmoidal composite I/O.",
  "text_access": "fulltext",
  "study_system": "mouse V1 acute slices, patch-clamp recordings from L5 pyramidal neurons + biophysical multi-compartmental modelling",
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  "replication_status": "independently_replicated",
  "claim_source_sentence": "L5 pyramidal neurons are the only neocortical cell type with dendrites reaching all six layers of cortex, casting them as one of the main integrators in the cortical column. Using a detailed multi-compartmental model, we show this physiological setup to be well suited for coincidence detection between basal and apical tuft inputs by controlling the frequency of spike output.",
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  "replication_evidence_dois": [
    "10.1038/s41586-026-10190-7"
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  "paper:pmid:25768881"
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L5 pyramidal neurons are the only neocortical cell type with dendrites reaching all six layers of cortex, casting them as one of the main integrators in the cortical column. Using a detailed multi-compartmental model, we show this physiological setup to be well suited for coincidence detection between basal and apical tuft inputs by controlling the frequency of spike output.

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