Version history

{
  "scope": "human fetal forebrain (early gestation through 19 PCW)",
  "claim_text": "In human fetal forebrain, secretagogin (SCGN)-expressing cortical GABAergic precursors arise from multiple subpallial origins (CGE, LGE, septum and preoptic area), are largely SP8+ and LHX6-negative, and migrate via diverse routes into neocortex, insular cortex, olfactory cortex and olfactory bulbs. By 19 post-conceptional weeks, SCGN is expressed in 58% of cortical-wall DLX2+ GABAergic neurons — a higher proportion than calretinin, identifying SCGN as a major marker of human (but not mouse) CGE/LGE-derived cortical INs.",
  "raw_fields": {
    "n": null,
    "doi": "10.3389/fnana.2020.00061",
    "claim": "In human fetal forebrain, secretagogin (SCGN)-expressing cortical GABAergic precursors arise from multiple subpallial origins (CGE, LGE, septum and preoptic area), are largely SP8+ and LHX6-negative, and migrate via diverse routes into neocortex, insular cortex, olfactory cortex and olfactory bulbs. By 19 post-conceptional weeks, SCGN is expressed in 58% of cortical-wall DLX2+ GABAergic neurons — a higher proportion than calretinin, identifying SCGN as a major marker of human (but not mouse) CGE/LGE-derived cortical INs.",
    "title": null,
    "cite_key": "Alzubi2020",
    "evidence": "IHC tracing across human fetal forebrain stages, including 19 PCW; comparison to adult mouse.",
    "effect_size": null,
    "figure_data": null,
    "text_access": "abstract_only",
    "key_entities": [
      "secretagogin",
      "SCGN",
      "SP8",
      "LHX6",
      "DLX2",
      "CGE",
      "LGE",
      "septum",
      "POA",
      "calretinin",
      "insular cortex",
      "olfactory",
      "human",
      "species difference"
    ],
    "study_system": "human fetal forebrain (early gestation through 19 PCW)",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "single_study",
    "_source_cluster_index": 137,
    "claim_source_sentence": "Multiple potential origins of SCGN-expressing neurons were identified in the caudal ganglionic eminence (CGE) lateral ganglionic eminence (LGE) septum and preoptic area; these cells largely co-expressed SP8 but not the medial ganglionic eminence marker LHX6. ... 58% of DLX2+ neurons expressed SCGN in the cortical wall at 19 post-conceptional weeks (PCW), a higher proportion than expressed calretinin, a marker for GABAergic neurons of LGE/CGE origin.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-30ca0d796dd6"
  ],
  "source_span": "Multiple potential origins of SCGN-expressing neurons were identified in the caudal ganglionic eminence (CGE) lateral ganglionic eminence (LGE) septum and preoptic area; these cells largely co-expressed SP8 but not the medial ganglionic eminence marker LHX6. ... 58% of DLX2+ neurons expressed SCGN in the cortical wall at 19 post-conceptional weeks (PCW), a higher proportion than expressed calretinin, a marker for GA...",
  "study_system": "human fetal forebrain (early gestation through 19 PCW)",
  "evidence_refs": [
    {
      "ref": "paper:paper-30ca0d796dd6"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "IHC tracing across human fetal forebrain stages, including 19 PCW; comparison to adult mouse.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}