In human fetal forebrain, secretagogin (SCGN)-expressing cortical GABAergic pre…

In human fetal forebrain, secretagogin (SCGN)-expressing cortical GABAergic precursors arise from multiple subpallial origins (CGE, LGE, septum and preoptic area), are largely SP8+ and LHX6-negative, and migrate via diverse routes into neocortex, insular cortex, olfactory cortex and olfactory bulbs. By 19 post-conceptional weeks, SCGN is expressed in 58% of cortical-wall DLX2+ GABAergic neurons — a higher proportion than calretinin, identifying SCGN as a major marker of human (but not mouse) CGE/LGE-derived cortical INs.

{
  "n": null,
  "doi": "10.3389/fnana.2020.00061",
  "claim": "In human fetal forebrain, secretagogin (SCGN)-expressing cortical GABAergic precursors arise from multiple subpallial origins (CGE, LGE, septum and preoptic area), are largely SP8+ and LHX6-negative, and migrate via diverse routes into neocortex, insular cortex, olfactory cortex and olfactory bulbs. By 19 post-conceptional weeks, SCGN is expressed in 58% of cortical-wall DLX2+ GABAergic neurons — a higher proportion than calretinin, identifying SCGN as a major marker of human (but not mouse) CGE/LGE-derived cortical INs.",
  "title": null,
  "cite_key": "Alzubi2020",
  "evidence": "IHC tracing across human fetal forebrain stages, including 19 PCW; comparison to adult mouse.",
  "effect_size": null,
  "figure_data": null,
  "text_access": "abstract_only",
  "key_entities": [
    "secretagogin",
    "SCGN",
    "SP8",
    "LHX6",
    "DLX2",
    "CGE",
    "LGE",
    "septum",
    "POA",
    "calretinin",
    "insular cortex",
    "olfactory",
    "human",
    "species difference"
  ],
  "study_system": "human fetal forebrain (early gestation through 19 PCW)",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "single_study",
  "_source_cluster_index": 137,
  "claim_source_sentence": "Multiple potential origins of SCGN-expressing neurons were identified in the caudal ganglionic eminence (CGE) lateral ganglionic eminence (LGE) septum and preoptic area; these cells largely co-expressed SP8 but not the medial ganglionic eminence marker LHX6. ... 58% of DLX2+ neurons expressed SCGN in the cortical wall at 19 post-conceptional weeks (PCW), a higher proportion than expressed calretinin, a marker for GABAergic neurons of LGE/CGE origin.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

[
  "paper:paper-30ca0d796dd6"
]

Multiple potential origins of SCGN-expressing neurons were identified in the caudal ganglionic eminence (CGE) lateral ganglionic eminence (LGE) septum and preoptic area; these cells largely co-expressed SP8 but not the medial ganglionic eminence marker LHX6. ... 58% of DLX2+ neurons expressed SCGN in the cortical wall at 19 post-conceptional weeks (PCW), a higher proportion than expressed calretinin, a marker for GA...

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