Version history

{
  "scope": "mouse intersectional genetic circuit dissection",
  "claim_text": "Although the ascending spiral synaptic connectivity is anatomically present, the SNr-to-SNc circuit cannot support straightforward disinhibition of dorsolateral striatal dopamine signaling as predicted by Haber's spiral hypothesis.",
  "raw_fields": {
    "n": 26,
    "doi": "10.1016/j.celrep.2022.111228",
    "claim": "Although the ascending spiral synaptic connectivity is anatomically present, the SNr-to-SNc circuit cannot support straightforward disinhibition of dorsolateral striatal dopamine signaling as predicted by Haber's spiral hypothesis.",
    "cite_key": "Ambrosi2022",
    "evidence": "Transsynaptic and intersectional genetic tools in mice tested both closed- and open-loop striatonigrostriatal circuits and found 69% (18/26) of recorded DLS-projecting DA neurons received monosynaptic SNr inhibition but the topology does not yield clean disinhibition.",
    "effect_size": "69% of DLS-projecting DA neurons receive SNr inhibition; 87% of DMS-projecting",
    "text_access": "fulltext",
    "study_system": "mouse intersectional genetic circuit dissection",
    "source_cluster_id": "cluster_06",
    "replication_status": "contested",
    "claim_source_sentence": "They find that synaptic connectivity in the ascending spiral is present, but the circuit cannot support straightforward disinhibition of DLS dopamine signaling.",
    "replication_evidence_dois": [
      "10.1038/nn1544"
    ],
    "effect_size_source_sentence": "Under this configuration, we found that 69% (18/26) of the recorded DLS-projecting neurons were monosynaptically inhibited by GABAergic SNr cells ( Figures 1E and 1F )."
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_07_evidence_package.json",
  "effect_size": "69% of DLS-projecting DA neurons receive SNr inhibition; 87% of DMS-projecting",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-07",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-e0c1ebf94719"
  ],
  "source_span": "They find that synaptic connectivity in the ascending spiral is present, but the circuit cannot support straightforward disinhibition of DLS dopamine signaling.",
  "study_system": "mouse intersectional genetic circuit dissection",
  "evidence_refs": [
    {
      "ref": "paper:paper-e0c1ebf94719"
    }
  ],
  "section_title": "Parallel Loop Channels: Motor, Limbic, Associative, and Beyond the Classic Three",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Transsynaptic and intersectional genetic tools in mice tested both closed- and open-loop striatonigrostriatal circuits and found 69% (18/26) of recorded DLS-projecting DA neurons received monosynaptic SNr inhibition but the topology does not yield clean disinhibition.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "contested",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-07",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_07_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}