Although the ascending spiral synaptic connectivity is anatomically present, th…

{
  "n": 26,
  "doi": "10.1016/j.celrep.2022.111228",
  "claim": "Although the ascending spiral synaptic connectivity is anatomically present, the SNr-to-SNc circuit cannot support straightforward disinhibition of dorsolateral striatal dopamine signaling as predicted by Haber's spiral hypothesis.",
  "cite_key": "Ambrosi2022",
  "evidence": "Transsynaptic and intersectional genetic tools in mice tested both closed- and open-loop striatonigrostriatal circuits and found 69% (18/26) of recorded DLS-projecting DA neurons received monosynaptic SNr inhibition but the topology does not yield clean disinhibition.",
  "effect_size": "69% of DLS-projecting DA neurons receive SNr inhibition; 87% of DMS-projecting",
  "text_access": "fulltext",
  "study_system": "mouse intersectional genetic circuit dissection",
  "source_cluster_id": "cluster_06",
  "replication_status": "contested",
  "claim_source_sentence": "They find that synaptic connectivity in the ascending spiral is present, but the circuit cannot support straightforward disinhibition of DLS dopamine signaling.",
  "replication_evidence_dois": [
    "10.1038/nn1544"
  ],
  "effect_size_source_sentence": "Under this configuration, we found that 69% (18/26) of the recorded DLS-projecting neurons were monosynaptically inhibited by GABAergic SNr cells ( Figures 1E and 1F )."
}

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Transsynaptic and intersectional genetic tools in mice tested both closed- and open-loop striatonigrostriatal circuits and found 69% (18/26) of recorded DLS-projecting DA neurons received monosynaptic SNr inhibition but the topology does not yield clean disinhibition.