Version history

{
  "scope": "CD-1 mouse, NAc, operant aggression self-administration",
  "claim_text": "Chemogenetic inactivation of nucleus accumbens Drd1-expressing neurons decreases aggression self-administration and aggression seeking in male CD-1 mice.",
  "raw_fields": {
    "n": 1,
    "doi": "10.1523/jneurosci.2409-18.2019",
    "claim": "Chemogenetic inactivation of nucleus accumbens Drd1-expressing neurons decreases aggression self-administration and aggression seeking in male CD-1 mice.",
    "cite_key": "Golden2019",
    "evidence": "DREADD (hM4Di) experiments in NAc Drd1 vs Drd2 neurons in operant aggression task.",
    "effect_size": "9 d",
    "text_access": "abstract_only",
    "study_system": "CD-1 mouse, NAc, operant aggression self-administration",
    "source_cluster_id": "cluster_10",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "To test the causal role of Drd1- and Drd2-expressing neurons, we validated a transgenic hybrid breeding strategy crossing inbred Drd1-Cre and Drd2-Cre transgenic mice with outbred CD-1 mice and used cell-type-specific Cre-DREADD (hM4Di) to inhibit NAc Drd1- and Drd2-expressing neuron activity.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "We trained CD-1 mice to self-administer intruders (9 d, 12 trials/d) and tested them for aggression self-administration and aggression seeking on abstinence Day 1."
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json",
  "effect_size": "9 d",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-11",
  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-305c2dc82909"
  ],
  "source_span": "To test the causal role of Drd1- and Drd2-expressing neurons, we validated a transgenic hybrid breeding strategy crossing inbred Drd1-Cre and Drd2-Cre transgenic mice with outbred CD-1 mice and used cell-type-specific Cre-DREADD (hM4Di) to inhibit NAc Drd1- and Drd2-expressing neuron activity.",
  "study_system": "CD-1 mouse, NAc, operant aggression self-administration",
  "evidence_refs": [
    {
      "ref": "paper:paper-305c2dc82909"
    }
  ],
  "section_title": "Cell-Type-Specific Dissection of Loop Circuits (Opto/Chemo/Tracing)",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "DREADD (hM4Di) experiments in NAc Drd1 vs Drd2 neurons in operant aggression task.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-11",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}