Chemogenetic inactivation of nucleus accumbens Drd1-expressing neurons decrease…

{
  "n": 1,
  "doi": "10.1523/jneurosci.2409-18.2019",
  "claim": "Chemogenetic inactivation of nucleus accumbens Drd1-expressing neurons decreases aggression self-administration and aggression seeking in male CD-1 mice.",
  "cite_key": "Golden2019",
  "evidence": "DREADD (hM4Di) experiments in NAc Drd1 vs Drd2 neurons in operant aggression task.",
  "effect_size": "9 d",
  "text_access": "abstract_only",
  "study_system": "CD-1 mouse, NAc, operant aggression self-administration",
  "source_cluster_id": "cluster_10",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "To test the causal role of Drd1- and Drd2-expressing neurons, we validated a transgenic hybrid breeding strategy crossing inbred Drd1-Cre and Drd2-Cre transgenic mice with outbred CD-1 mice and used cell-type-specific Cre-DREADD (hM4Di) to inhibit NAc Drd1- and Drd2-expressing neuron activity.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "We trained CD-1 mice to self-administer intruders (9 d, 12 trials/d) and tested them for aggression self-administration and aggression seeking on abstinence Day 1."
}

[
  "paper:paper-305c2dc82909"
]

To test the causal role of Drd1- and Drd2-expressing neurons, we validated a transgenic hybrid breeding strategy crossing inbred Drd1-Cre and Drd2-Cre transgenic mice with outbred CD-1 mice and used cell-type-specific Cre-DREADD (hM4Di) to inhibit NAc Drd1- and Drd2-expressing neuron activity.

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