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- Live5/17/2026, 4:35:28 PM
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{ "scope": "Mouse S1, 2P calcium imaging", "claim_text": "In-vivo two-photon calcium imaging in mouse primary somatosensory cortex (S1) showed that sound-evoked spiking occurs in an extremely small fraction of cells, with sparse auditory activity that does not encode stimulus identity nor audio-tactile feature conjunctions, and that this cross-modal influence is unchanged after passive experience or reinforcement — bounding what 'multisensory integration in primary sensory cortex' actually means in mouse cortex.", "raw_fields": { "n": 0, "doi": "10.1016/j.neuron.2024.10.020", "claim": "In-vivo two-photon calcium imaging in mouse primary somatosensory cortex (S1) showed that sound-evoked spiking occurs in an extremely small fraction of cells, with sparse auditory activity that does not encode stimulus identity nor audio-tactile feature conjunctions, and that this cross-modal influence is unchanged after passive experience or reinforcement — bounding what 'multisensory integration in primary sensory cortex' actually means in mouse cortex.", "cite_key": "Kato2025", "evidence": "2P calcium imaging in mouse S1 across naive and trained mice; quantitative absence of auditory feature encoding.", "effect_size": "auditory and audio-tactile stimulus encoding unchanged by passive experience or reinforcement", "text_access": "abstract_only", "study_system": "Mouse S1, 2P calcium imaging", "argument_role": "supporting", "replication_status": "single-study", "claim_source_sentence": "We found sound-evoked spiking activity in an extremely small fraction of cells, and this sparse activity did not encode auditory stimulus identity. Moreover, S1 did not encode information about specific audio-tactile feature conjunctions. Auditory and audio-tactile stimulus encoding remained unchanged after both passive experience and reinforcement.", "source_provenance_status": "non_substring_match", "replication_evidence_dois": [], "effect_size_source_sentence": "Auditory and audio-tactile stimulus encoding remained unchanged after both passive experience and reinforcement." }, "section_id": "section_15", "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_15_evidence_package.json", "effect_size": "auditory and audio-tactile stimulus encoding unchanged by passive experience or reinforcement", "review_repo": "ComputationalReviewRecurrence", "section_ref": "wiki_page:computationalreviewrecurrence-15-methods-limits", "source_kind": "review_finding", "source_path": "evidence/section_15_evidence_package.json", "source_refs": [ "paper:paper-023db353b69d" ], "source_span": "We found sound-evoked spiking activity in an extremely small fraction of cells, and this sparse activity did not encode auditory stimulus identity. Moreover, S1 did not encode information about specific audio-tactile feature conjunctions. Auditory and audio-tactile stimulus encoding remained unchanged after both passive experience and reinforcement.", "study_system": "Mouse S1, 2P calcium imaging", "evidence_refs": [ { "ref": "paper:paper-023db353b69d" } ], "section_title": "15. Methodological limits and emerging tools — what current mouse-cortex tools cannot yet measure about E→E recurrence (subthreshold network activity, fast plasticity in vivo, millimetre-scale dynamic connectomes), and what is on the near horizon", "source_policy": { "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }, "evidence_summary": "2P calcium imaging in mouse S1 across naive and trained mice; quantitative absence of auditory feature encoding.", "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9", "replication_status": "single-study", "review_package_ref": "analysis_bundle:ab-d9c479db9be9", "source_artifact_ref": "wiki_page:computationalreviewrecurrence-15-methods-limits", "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_15_evidence_package.json", "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "created_by": "persona-jerome-lecoq-gbo-neuroscience", "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }