The transcription factor St18 specifies GPe projection-neuron identity within t…

{
  "n": null,
  "doi": "10.1038/s41467-022-35518-5",
  "claim": "The transcription factor St18 specifies GPe projection-neuron identity within the medial ganglionic eminence lineage, with St18 loss disrupting prototypic vs arkypallidal differentiation.",
  "cite_key": "Nunnelly2022",
  "evidence": "Conditional St18 deletion and lineage tracing in mouse GPe.",
  "effect_size": "see source sentence",
  "text_access": "fulltext",
  "study_system": "mouse (conditional KO; in situ + tracing)",
  "source_cluster_id": "cluster_02",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Genetic loss of function of St18 reveals a specific reduction in GPe prototypic neurons, a projection neuron population originating from the MGE. scRNA-seq analysis of the MGE indicated that St18 regulates progenitor cell specification, which manifests as altered neuronal output.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "At E12.5, we found that St18 transcript is present in the MGE subventricular zone (SVZ) and mantle (Fig."
}

[
  "paper:paper-0aae9930933d"
]

Genetic loss of function of St18 reveals a specific reduction in GPe prototypic neurons, a projection neuron population originating from the MGE. scRNA-seq analysis of the MGE indicated that St18 regulates progenitor cell specification, which manifests as altered neuronal output.

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