Details
- scope
- mouse, St18 knockout
- claim_text
- St18 regulates the choice between projection neuron and interneuron identity in MGE lineages; loss expands cortical interneurons at the expense of GPe projection neurons
- section_id
- section_03_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
- effect_size
- large expansion of nascent cortical interneurons at expense of GPe neurons
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-03
- source_kind
- review_finding
- source_path
- evidence/section_03_evidence_package.json
- source_span
- we observe a large expansion of nascent cortical interneurons at the expense of putative GPe neurons in St18 null embryos
- study_system
- mouse, St18 knockout
- section_title
- Developmental Origins: MGE Lineage, Specification, and Migration
- evidence_summary
- St18 influences cell fate in MGE lineages; downstream Cbx7 (PRC1 component) is essential for projection neuron-like migration but not morphology
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-03
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1038/s41467-022-35518-5", "claim": "St18 regulates the choice between projection neuron and interneuron identity in MGE lineages; loss expands cortical interneurons at the expense of GPe projection neurons", "evidence": "St18 influences cell fate in MGE lineages; downstream Cbx7 (PRC1 component) is essential for projection neuron-like migration but not morphology", "effect_size": "large expansion of nascent cortical interneurons at expense of GPe neurons", "text_access": "fulltext", "study_system": "mouse, St18 knockout", "replication_status": "replication_unknown", "claim_source_sentence": "we observe a large expansion of nascent cortical interneurons at the expense of putative GPe neurons in St18 null embryos", "replication_evidence_dois": [], "effect_size_source_sentence": "we observe a large expansion of nascent cortical interneurons at the expense of putative GPe neurons in St18 null embryos" }- source_refs
[ "paper:paper-0aae9930933d" ]
- evidence_refs
[ { "ref": "paper:paper-0aae9930933d" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }