- claim_text
Both PV and SST interneurons are critically required for slow hippocampal gamma oscillations; additionally, intense SST interneuron activation combined with network excitation can generate fast gamma oscillations, showing both cell types are needed for the full gamma spectrum
- raw_fields
{
"n": 0,
"doi": "10.1523/jneurosci.0261-20.2020",
"claim": "Both PV and SST interneurons are critically required for slow hippocampal gamma oscillations; additionally, intense SST interneuron activation combined with network excitation can generate fast gamma oscillations, showing both cell types are needed for the full gamma spectrum",
"evidence": "Optogenetic manipulation of PV and SST populations during cholinergically induced gamma in mouse hippocampal CA3 slices",
"effect_size": "Both PV and SST disruption decreased slow gamma power; SST photoexcitation induced fast gamma",
"text_access": "abstract_only",
"study_system": "mouse hippocampal CA3 slices, in vitro optogenetics",
"replication_status": "single study",
"claim_source_sentence": "Disrupting either PV+ or SST+ interneuron activity, via either photoinhibition or photoexcitation, led to a decrease in the power of cholinergically induced slow gamma oscillations. Furthermore, photoexcitation of SST+ interneurons induced fast gamma oscillations, which depended on both synaptic excitation and inhibition.",
"replication_evidence_dois": [],
"effect_size_source_sentence": "Disrupting either PV+ or SST+ interneuron activity led to a decrease in the power of cholinergically induced slow gamma oscillations. Photoexcitation of SST+ interneurons induced fast gamma oscillations."
}- source_refs
[
"paper:paper-4d3be038bd01"
]
- source_span
Disrupting either PV+ or SST+ interneuron activity, via either photoinhibition or photoexcitation, led to a decrease in the power of cholinergically induced slow gamma oscillations. Furthermore, photoexcitation of SST+ interneurons induced fast gamma oscillations, which depended on both synaptic excitation and inhibition.
- evidence_refs
[
{
"ref": "paper:paper-4d3be038bd01"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}