Version history

{
  "scope": "mouse hippocampal CA3 slices, in vitro optogenetics",
  "claim_text": "Both PV and SST interneurons are critically required for slow hippocampal gamma oscillations; additionally, intense SST interneuron activation combined with network excitation can generate fast gamma oscillations, showing both cell types are needed for the full gamma spectrum",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.0261-20.2020",
    "claim": "Both PV and SST interneurons are critically required for slow hippocampal gamma oscillations; additionally, intense SST interneuron activation combined with network excitation can generate fast gamma oscillations, showing both cell types are needed for the full gamma spectrum",
    "evidence": "Optogenetic manipulation of PV and SST populations during cholinergically induced gamma in mouse hippocampal CA3 slices",
    "effect_size": "Both PV and SST disruption decreased slow gamma power; SST photoexcitation induced fast gamma",
    "text_access": "abstract_only",
    "study_system": "mouse hippocampal CA3 slices, in vitro optogenetics",
    "replication_status": "single study",
    "claim_source_sentence": "Disrupting either PV+ or SST+ interneuron activity, via either photoinhibition or photoexcitation, led to a decrease in the power of cholinergically induced slow gamma oscillations. Furthermore, photoexcitation of SST+ interneurons induced fast gamma oscillations, which depended on both synaptic excitation and inhibition.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Disrupting either PV+ or SST+ interneuron activity led to a decrease in the power of cholinergically induced slow gamma oscillations. Photoexcitation of SST+ interneurons induced fast gamma oscillations."
  },
  "section_id": "section_07_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_07_evidence_package.json",
  "effect_size": "Both PV and SST disruption decreased slow gamma power; SST photoexcitation induced fast gamma",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-07",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-4d3be038bd01"
  ],
  "source_span": "Disrupting either PV+ or SST+ interneuron activity, via either photoinhibition or photoexcitation, led to a decrease in the power of cholinergically induced slow gamma oscillations. Furthermore, photoexcitation of SST+ interneurons induced fast gamma oscillations, which depended on both synaptic excitation and inhibition.",
  "study_system": "mouse hippocampal CA3 slices, in vitro optogenetics",
  "evidence_refs": [
    {
      "ref": "paper:paper-4d3be038bd01"
    }
  ],
  "section_title": "Local Circuit Motifs: Perisomatic Inhibition, Feedback, and Feedforward",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Optogenetic manipulation of PV and SST populations during cholinergically induced gamma in mouse hippocampal CA3 slices",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "single study",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-07",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_07_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}