Version history

{
  "scope": "mouse forelimb M1 slices; glutamate LSPS + paired recordings",
  "claim_text": "In mouse forelimb M1, L4-fated zone neurons receive intralaminar input and project predominantly upward to L2/3, replicating the unidirectional L4→L2/3 motif of sensory cortex within a motor area.",
  "raw_fields": {
    "n": "mouse M1 forelimb area, multiple slice maps + paired recordings",
    "doi": "10.7554/elife.05422",
    "claim": "In mouse forelimb M1, L4-fated zone neurons receive intralaminar input and project predominantly upward to L2/3, replicating the unidirectional L4→L2/3 motif of sensory cortex within a motor area.",
    "cite_key": "Yamawaki2014",
    "evidence": "Glutamate-uncaging LSPS input maps of identified L4-like neurons in forelimb M1 plus paired recordings; the maps show paucity of input outside L4 and an L4→L2/3 excitatory projection in M1 analogous to barrel cortex.",
    "effect_size": "L4→L2/3 projection identified at a normalized cortical depth of ∼1/3; quantitative connection probability reported in figures",
    "text_access": "fulltext",
    "study_system": "mouse forelimb M1 slices; glutamate LSPS + paired recordings",
    "argument_role": "supporting",
    "replication_status": "consistent with sensory cortex L4→L2/3 motif; novel for M1",
    "claim_source_sentence": "the L3/5A border, at a normalized cortical depth of ∼1/3, confirming the presence of a L4→2/3 excitatory projection in M1. A characteristic feature of L4 in sensory cortex is that the projection from L4 to L2/3 is primarily unidirectional, as L4 neurons receive primarily intralaminar excitatory input.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2004.05.002"
    ],
    "effect_size_source_sentence": "at a normalized cortical depth of ∼1/3, confirming the presence of a L4→2/3 excitatory projection in M1."
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "L4→L2/3 projection identified at a normalized cortical depth of ∼1/3; quantitative connection probability reported in figures",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-a29242ac688f"
  ],
  "source_span": "the L3/5A border, at a normalized cortical depth of ∼1/3, confirming the presence of a L4→2/3 excitatory projection in M1. A characteristic feature of L4 in sensory cortex is that the projection from L4 to L2/3 is primarily unidirectional, as L4 neurons receive primarily intralaminar excitatory input.",
  "study_system": "mouse forelimb M1 slices; glutamate LSPS + paired recordings",
  "evidence_refs": [
    {
      "ref": "paper:paper-a29242ac688f"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Glutamate-uncaging LSPS input maps of identified L4-like neurons in forelimb M1 plus paired recordings; the maps show paucity of input outside L4 and an L4→L2/3 excitatory projection in M1 analogous to barrel cortex.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "consistent with sensory cortex L4→L2/3 motif; novel for M1",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}