In mouse forelimb M1, L4-fated zone neurons receive intralaminar input and proj…

{
  "n": "mouse M1 forelimb area, multiple slice maps + paired recordings",
  "doi": "10.7554/elife.05422",
  "claim": "In mouse forelimb M1, L4-fated zone neurons receive intralaminar input and project predominantly upward to L2/3, replicating the unidirectional L4→L2/3 motif of sensory cortex within a motor area.",
  "cite_key": "Yamawaki2014",
  "evidence": "Glutamate-uncaging LSPS input maps of identified L4-like neurons in forelimb M1 plus paired recordings; the maps show paucity of input outside L4 and an L4→L2/3 excitatory projection in M1 analogous to barrel cortex.",
  "effect_size": "L4→L2/3 projection identified at a normalized cortical depth of ∼1/3; quantitative connection probability reported in figures",
  "text_access": "fulltext",
  "study_system": "mouse forelimb M1 slices; glutamate LSPS + paired recordings",
  "argument_role": "supporting",
  "replication_status": "consistent with sensory cortex L4→L2/3 motif; novel for M1",
  "claim_source_sentence": "the L3/5A border, at a normalized cortical depth of ∼1/3, confirming the presence of a L4→2/3 excitatory projection in M1. A characteristic feature of L4 in sensory cortex is that the projection from L4 to L2/3 is primarily unidirectional, as L4 neurons receive primarily intralaminar excitatory input.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.1016/j.neuron.2004.05.002"
  ],
  "effect_size_source_sentence": "at a normalized cortical depth of ∼1/3, confirming the presence of a L4→2/3 excitatory projection in M1."
}

[
  "paper:paper-a29242ac688f"
]

the L3/5A border, at a normalized cortical depth of ∼1/3, confirming the presence of a L4→2/3 excitatory projection in M1. A characteristic feature of L4 in sensory cortex is that the projection from L4 to L2/3 is primarily unidirectional, as L4 neurons receive primarily intralaminar excitatory input.

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    "Local review repositories are read-only inputs.",
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