Version history

{
  "scope": "mouse S1 cortex (Vip-IRES-cre × tdTomato), P3–P36",
  "claim_text": "Postnatal VIP-IN maturation in mouse S1 barrel cortex follows a sequential pattern (P3 → P30+): mEPSC frequency increases before P8–10 (excitatory synaptogenesis precedes inhibitory), mIPSC frequency increases at P14–16, and the E/I charge-transfer ratio remains constant across development.",
  "raw_fields": {
    "n": null,
    "doi": "10.1111/apha.14265",
    "claim": "Postnatal VIP-IN maturation in mouse S1 barrel cortex follows a sequential pattern (P3 → P30+): mEPSC frequency increases before P8–10 (excitatory synaptogenesis precedes inhibitory), mIPSC frequency increases at P14–16, and the E/I charge-transfer ratio remains constant across development.",
    "title": null,
    "cite_key": "Simacek2025b",
    "evidence": "Whole-cell patch-clamp on Vip-IRES-cre × tdTomato mice at P3–4, P8–10, P14–16, P30–36 in S1 barrel cortex; mEPSCs/mIPSCs/sEPSCs/sIPSCs measured.",
    "effect_size": null,
    "figure_data": null,
    "text_access": "fulltext",
    "key_entities": [
      "VIP",
      "Vip-IRES-cre",
      "postnatal maturation",
      "S1 barrel cortex",
      "E/I balance",
      "critical period",
      "whisking",
      "mEPSC",
      "mIPSC"
    ],
    "study_system": "mouse S1 cortex (Vip-IRES-cre × tdTomato), P3–P36",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "single_study",
    "_source_cluster_index": 121,
    "claim_source_sentence": "Excitatory and inhibitory postsynaptic currents (EPSCs and IPSCs) showed progressive VIP-IN integration into cortical networks, likely via synaptogenesis: mEPSC frequency increased before P8–10, while mIPSC frequency increased at P14–16. ... the E/I ratio of synaptic inputs, defined as a ratio of mEPSC to mIPSC charge transfer, remained constant throughout the investigated developmental stages.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-b709c20d2cb8"
  ],
  "source_span": "Excitatory and inhibitory postsynaptic currents (EPSCs and IPSCs) showed progressive VIP-IN integration into cortical networks, likely via synaptogenesis: mEPSC frequency increased before P8–10, while mIPSC frequency increased at P14–16. ... the E/I ratio of synaptic inputs, defined as a ratio of mEPSC to mIPSC charge transfer, remained constant throughout the investigated developmental stages.",
  "study_system": "mouse S1 cortex (Vip-IRES-cre × tdTomato), P3–P36",
  "evidence_refs": [
    {
      "ref": "paper:paper-b709c20d2cb8"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Whole-cell patch-clamp on Vip-IRES-cre × tdTomato mice at P3–4, P8–10, P14–16, P30–36 in S1 barrel cortex; mEPSCs/mIPSCs/sEPSCs/sIPSCs measured.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}