Postnatal VIP-IN maturation in mouse S1 barrel cortex follows a sequential patt…

Postnatal VIP-IN maturation in mouse S1 barrel cortex follows a sequential pattern (P3 → P30+): mEPSC frequency increases before P8–10 (excitatory synaptogenesis precedes inhibitory), mIPSC frequency increases at P14–16, and the E/I charge-transfer ratio remains constant across development.

{
  "n": null,
  "doi": "10.1111/apha.14265",
  "claim": "Postnatal VIP-IN maturation in mouse S1 barrel cortex follows a sequential pattern (P3 → P30+): mEPSC frequency increases before P8–10 (excitatory synaptogenesis precedes inhibitory), mIPSC frequency increases at P14–16, and the E/I charge-transfer ratio remains constant across development.",
  "title": null,
  "cite_key": "Simacek2025b",
  "evidence": "Whole-cell patch-clamp on Vip-IRES-cre × tdTomato mice at P3–4, P8–10, P14–16, P30–36 in S1 barrel cortex; mEPSCs/mIPSCs/sEPSCs/sIPSCs measured.",
  "effect_size": null,
  "figure_data": null,
  "text_access": "fulltext",
  "key_entities": [
    "VIP",
    "Vip-IRES-cre",
    "postnatal maturation",
    "S1 barrel cortex",
    "E/I balance",
    "critical period",
    "whisking",
    "mEPSC",
    "mIPSC"
  ],
  "study_system": "mouse S1 cortex (Vip-IRES-cre × tdTomato), P3–P36",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "single_study",
  "_source_cluster_index": 121,
  "claim_source_sentence": "Excitatory and inhibitory postsynaptic currents (EPSCs and IPSCs) showed progressive VIP-IN integration into cortical networks, likely via synaptogenesis: mEPSC frequency increased before P8–10, while mIPSC frequency increased at P14–16. ... the E/I ratio of synaptic inputs, defined as a ratio of mEPSC to mIPSC charge transfer, remained constant throughout the investigated developmental stages.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

[
  "paper:paper-b709c20d2cb8"
]

Excitatory and inhibitory postsynaptic currents (EPSCs and IPSCs) showed progressive VIP-IN integration into cortical networks, likely via synaptogenesis: mEPSC frequency increased before P8–10, while mIPSC frequency increased at P14–16. ... the E/I ratio of synaptic inputs, defined as a ratio of mEPSC to mIPSC charge transfer, remained constant throughout the investigated developmental stages.

[
  {
    "ref": "paper:paper-b709c20d2cb8"
  }
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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