- claim_text
All-optical read/write of approximately 10⁴ monitored and 10³ activated neurons across mouse cortical areas — an order-of-magnitude leap over prior capacity — uncovered deep L2/3 SST interneurons responsive to diverse activated ensembles, defying simple like-to-like wiring rules.
- raw_fields
{
"n": 10000,
"doi": "10.1101/2025.10.21.683734",
"claim": "All-optical read/write of approximately 10⁴ monitored and 10³ activated neurons across mouse cortical areas — an order-of-magnitude leap over prior capacity — uncovered deep L2/3 SST interneurons responsive to diverse activated ensembles, defying simple like-to-like wiring rules.",
"cite_key": "Drinnenberg2025",
"evidence": "Direct measurement of the current frontier of all-optical interrogation in mouse cortex, with a finding that bears on cluster_14's synthesis of what large-scale E→E recording supports about wiring rules.",
"effect_size": "~10³ optogenetically controlled neurons; ~10⁴ simultaneously monitored neurons (order-of-magnitude over prior)",
"text_access": "abstract_only",
"study_system": "Awake mouse cortex; all-optical large-scale read/write",
"argument_role": "supporting",
"replication_status": "single-study",
"claim_source_sentence": "Here, we present an all-optical strategy for precise optogenetic activity control of ∼10 3 neurons and simultaneous activity monitoring of ∼10 4 neurons within and across areas of mouse cortex—an order-of-magnitude leap beyond previous capabilities.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [],
"effect_size_source_sentence": "Here, we present an all-optical strategy for precise optogenetic activity control of ∼10 3 neurons and simultaneous activity monitoring of ∼10 4 neurons within and across areas of mouse cortex—an order-of-magnitude leap beyond previous capabilities."
}- source_refs
[
"paper:paper-8d923acf5f56"
]
- source_span
Here, we present an all-optical strategy for precise optogenetic activity control of ∼10 3 neurons and simultaneous activity monitoring of ∼10 4 neurons within and across areas of mouse cortex—an order-of-magnitude leap beyond previous capabilities.
- evidence_refs
[
{
"ref": "paper:paper-8d923acf5f56"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}