Version history

{
  "scope": "Awake mouse cortex; all-optical large-scale read/write",
  "claim_text": "All-optical read/write of approximately 10⁴ monitored and 10³ activated neurons across mouse cortical areas — an order-of-magnitude leap over prior capacity — uncovered deep L2/3 SST interneurons responsive to diverse activated ensembles, defying simple like-to-like wiring rules.",
  "raw_fields": {
    "n": 10000,
    "doi": "10.1101/2025.10.21.683734",
    "claim": "All-optical read/write of approximately 10⁴ monitored and 10³ activated neurons across mouse cortical areas — an order-of-magnitude leap over prior capacity — uncovered deep L2/3 SST interneurons responsive to diverse activated ensembles, defying simple like-to-like wiring rules.",
    "cite_key": "Drinnenberg2025",
    "evidence": "Direct measurement of the current frontier of all-optical interrogation in mouse cortex, with a finding that bears on cluster_14's synthesis of what large-scale E→E recording supports about wiring rules.",
    "effect_size": "~10³ optogenetically controlled neurons; ~10⁴ simultaneously monitored neurons (order-of-magnitude over prior)",
    "text_access": "abstract_only",
    "study_system": "Awake mouse cortex; all-optical large-scale read/write",
    "argument_role": "supporting",
    "replication_status": "single-study",
    "claim_source_sentence": "Here, we present an all-optical strategy for precise optogenetic activity control of ∼10  3 neurons and simultaneous activity monitoring of ∼10  4 neurons within and across areas of mouse cortex—an order-of-magnitude leap beyond previous capabilities.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Here, we present an all-optical strategy for precise optogenetic activity control of ∼10  3 neurons and simultaneous activity monitoring of ∼10  4 neurons within and across areas of mouse cortex—an order-of-magnitude leap beyond previous capabilities."
  },
  "section_id": "section_16",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_16_evidence_package.json",
  "effect_size": "~10³ optogenetically controlled neurons; ~10⁴ simultaneously monitored neurons (order-of-magnitude over prior)",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-16-synthesis",
  "source_kind": "review_finding",
  "source_path": "evidence/section_16_evidence_package.json",
  "source_refs": [
    "paper:paper-8d923acf5f56"
  ],
  "source_span": "Here, we present an all-optical strategy for precise optogenetic activity control of ∼10 3 neurons and simultaneous activity monitoring of ∼10 4 neurons within and across areas of mouse cortex—an order-of-magnitude leap beyond previous capabilities.",
  "study_system": "Awake mouse cortex; all-optical large-scale read/write",
  "evidence_refs": [
    {
      "ref": "paper:paper-8d923acf5f56"
    }
  ],
  "section_title": "16. Synthesis — which computational claims the mouse-cortex E→E empirical record actually supports, where the bottleneck observations are, and what an inhibition-free, single-species, basic-research analytic framing misses",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Direct measurement of the current frontier of all-optical interrogation in mouse cortex, with a finding that bears on cluster_14's synthesis of what large-scale E→E recording supports about wiring rules.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-16-synthesis",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_16_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}