Version history

{
  "scope": "J20-APP Alzheimer's disease mouse model, optogenetics",
  "claim_text": "Optogenetic stimulation of medial septal PV neurons at 40 Hz (but not 80 Hz) restores hippocampal slow gamma oscillation amplitude and phase-amplitude coupling in an AD mouse model, rescuing spatial memory despite significant plaque deposition",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/s41467-019-13260-9",
    "claim": "Optogenetic stimulation of medial septal PV neurons at 40 Hz (but not 80 Hz) restores hippocampal slow gamma oscillation amplitude and phase-amplitude coupling in an AD mouse model, rescuing spatial memory despite significant plaque deposition",
    "evidence": "Optogenetic stimulation of medial septal PV neurons at 40 Hz (but not 80 Hz) restores hippocampal slow gamma oscillation amplitude and phase-amplitude coupling in an AD mouse model, rescuing spatial memory despite significant plaque deposition",
    "effect_size": "40 Hz stimulation rescued spatial memory; 80 Hz had no effect",
    "text_access": "fulltext",
    "study_system": "J20-APP Alzheimer's disease mouse model, optogenetics",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "We show that optogenetic stimulation of parvalbumin neurons at 40 Hz (but not 80 Hz) restores hippocampal slow gamma oscillations amplitude, and phase-amplitude coupling of the J20 AD mouse model.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Restoration of slow gamma oscillations during retrieval rescued spatial memory in mice despite significant plaque deposition."
  },
  "section_id": "section_10_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_10_evidence_package.json",
  "effect_size": "40 Hz stimulation rescued spatial memory; 80 Hz had no effect",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-10",
  "source_kind": "review_finding",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:paper-1e2283ee86f9"
  ],
  "source_span": "We show that optogenetic stimulation of parvalbumin neurons at 40 Hz (but not 80 Hz) restores hippocampal slow gamma oscillations amplitude, and phase-amplitude coupling of the J20 AD mouse model.",
  "study_system": "J20-APP Alzheimer's disease mouse model, optogenetics",
  "evidence_refs": [
    {
      "ref": "paper:paper-1e2283ee86f9"
    }
  ],
  "section_title": "Oscillations and Network Dynamics: Gamma, Ripples, and Synchrony",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Optogenetic stimulation of medial septal PV neurons at 40 Hz (but not 80 Hz) restores hippocampal slow gamma oscillation amplitude and phase-amplitude coupling in an AD mouse model, rescuing spatial memory despite significant plaque deposition",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-10",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_10_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}