- claim_text
Optogenetic stimulation of medial septal PV neurons at 40 Hz (but not 80 Hz) restores hippocampal slow gamma oscillation amplitude and phase-amplitude coupling in an AD mouse model, rescuing spatial memory despite significant plaque deposition
- raw_fields
{
"n": 0,
"doi": "10.1038/s41467-019-13260-9",
"claim": "Optogenetic stimulation of medial septal PV neurons at 40 Hz (but not 80 Hz) restores hippocampal slow gamma oscillation amplitude and phase-amplitude coupling in an AD mouse model, rescuing spatial memory despite significant plaque deposition",
"evidence": "Optogenetic stimulation of medial septal PV neurons at 40 Hz (but not 80 Hz) restores hippocampal slow gamma oscillation amplitude and phase-amplitude coupling in an AD mouse model, rescuing spatial memory despite significant plaque deposition",
"effect_size": "40 Hz stimulation rescued spatial memory; 80 Hz had no effect",
"text_access": "fulltext",
"study_system": "J20-APP Alzheimer's disease mouse model, optogenetics",
"replication_status": "replication_unknown",
"claim_source_sentence": "We show that optogenetic stimulation of parvalbumin neurons at 40 Hz (but not 80 Hz) restores hippocampal slow gamma oscillations amplitude, and phase-amplitude coupling of the J20 AD mouse model.",
"replication_evidence_dois": [],
"effect_size_source_sentence": "Restoration of slow gamma oscillations during retrieval rescued spatial memory in mice despite significant plaque deposition."
}- source_refs
[
"paper:paper-1e2283ee86f9"
]
- evidence_refs
[
{
"ref": "paper:paper-1e2283ee86f9"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}- evidence_summary
Optogenetic stimulation of medial septal PV neurons at 40 Hz (but not 80 Hz) restores hippocampal slow gamma oscillation amplitude and phase-amplitude coupling in an AD mouse model, rescuing spatial memory despite significant plaque deposition