- claim_text
In mouse prelimbic prefrontal cortex, D1 dopamine receptors are enriched in pyramidal cells of L5 and L6 that project to intratelencephalic targets (contralateral cortex, striatum, claustrum) rather than to extratelencephalic structures, and in superficial-layer VIP+/calretinin+ interneurons, while absent from PV+ and SOM+ interneurons.
- raw_fields
{
"n": null,
"doi": "10.1093/cercor/bhy299",
"claim": "In mouse prelimbic prefrontal cortex, D1 dopamine receptors are enriched in pyramidal cells of L5 and L6 that project to intratelencephalic targets (contralateral cortex, striatum, claustrum) rather than to extratelencephalic structures, and in superficial-layer VIP+/calretinin+ interneurons, while absent from PV+ and SOM+ interneurons.",
"cite_key": "Anastasiades2019",
"evidence": "Cell-type-specific BAC-EGFP and retrograde tracer labelling combined with whole-cell recordings and D1 agonist application in mouse prelimbic PFC.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "mouse prelimbic prefrontal cortex, L5/L6 IT and PT cells and interneuron subtypes",
"argument_role": "supporting",
"replication_status": "replication_unknown",
"claim_source_sentence": "We first show that D1 receptors are enriched in pyramidal cells in both layers 5 and 6, and that these cells project to intratelencephalic targets including contralateral cortex, striatum, and claustrum rather than to extratelencephalic structures... D1 receptors are also present in interneurons and enriched in superficial layer VIP-positive (VIP+) interneurons that coexpresses calretinin but absent from parvalbumin-positive (PV+) and somatostatin-positive (SOM+) interneurons.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-54d3b0c8acb7"
]
- source_span
We first show that D1 receptors are enriched in pyramidal cells in both layers 5 and 6, and that these cells project to intratelencephalic targets including contralateral cortex, striatum, and claustrum rather than to extratelencephalic structures... D1 receptors are also present in interneurons and enriched in superficial layer VIP-positive (VIP+) interneurons that coexpresses calretinin but absent from parvalbumin...
- evidence_refs
[
{
"ref": "paper:paper-54d3b0c8acb7"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}