In mouse V1 L2/3, paired recordings combined with in vivo two-photon imaging sh…

In mouse V1 L2/3, paired recordings combined with in vivo two-photon imaging show that connection probability between pyramidal pairs scales with similarity of visual responses — pairs sharing orientation preference connect at roughly twice the rate of orthogonally tuned pairs.

{
  "n": 0,
  "doi": "10.1038/nature09880",
  "claim": "In mouse V1 L2/3, paired recordings combined with in vivo two-photon imaging show that connection probability between pyramidal pairs scales with similarity of visual responses — pairs sharing orientation preference connect at roughly twice the rate of orthogonally tuned pairs.",
  "cite_key": "Ko2011",
  "evidence": "In vivo two-photon characterization of visual responses followed by in vitro multiple whole-cell paired recordings in mouse V1 L2/3.",
  "effect_size": "~2× higher connection rate for iso-orientation vs orthogonally tuned L2/3 pairs.",
  "text_access": "abstract_only",
  "study_system": "mouse V1, L2/3 pyramidal pairs; in vivo 2P + in vitro paired patch",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "We found that connection probability was related to the similarity of visually driven neuronal activity. Neurons with the same preference for oriented stimuli connected at twice the rate of neurons with orthogonal orientation preferences.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1038/nature12015",
    "10.1038/nature14182"
  ],
  "effect_size_source_sentence": "Neurons with the same preference for oriented stimuli connected at twice the rate of neurons with orthogonal orientation preferences."
}

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