Version history

{
  "scope": "mouse V1 layer 2/3 pyramidal neurons (in vitro)",
  "claim_text": "In mouse V1 slices, optogenetic co-activation of layer 2/3 pyramidal neurons produces persistent increases in neuronal excitability (reduced spike threshold, increased input resistance) that, more than synaptic plasticity, mediate ensemble formation.",
  "raw_fields": {
    "n": null,
    "doi": "10.7554/elife.77470",
    "claim": "In mouse V1 slices, optogenetic co-activation of layer 2/3 pyramidal neurons produces persistent increases in neuronal excitability (reduced spike threshold, increased input resistance) that, more than synaptic plasticity, mediate ensemble formation.",
    "cite_key": "AlejandreGarcia2022",
    "evidence": "Whole-cell + perforated-patch paired recordings in acute V1 slices after optogenetic ensemble induction; pharmacological reversal by blocking membrane-resistance changes.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "mouse V1 layer 2/3 pyramidal neurons (in vitro)",
    "argument_role": "supporting",
    "replication_status": "single_study",
    "claim_source_sentence": "In addition, we observed unexpected strong and persistent increases in neuronal excitability after stimulation, with increases in membrane resistance and reductions in spike threshold.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_11_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-11-pattern-completion",
  "source_kind": "review_finding",
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  "source_span": "In addition, we observed unexpected strong and persistent increases in neuronal excitability after stimulation, with increases in membrane resistance and reductions in spike threshold.",
  "study_system": "mouse V1 layer 2/3 pyramidal neurons (in vitro)",
  "evidence_refs": [
    {
      "ref": "paper:paper-8acf0afd8926"
    }
  ],
  "section_title": "11. Physiological signature III — pattern completion, replay, and sequence generation as recurrent-circuit read-outs in mouse cortex",
  "source_policy": {
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    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
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  "evidence_summary": "Whole-cell + perforated-patch paired recordings in acute V1 slices after optogenetic ensemble induction; pharmacological reversal by blocking membrane-resistance changes.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-11-pattern-completion",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_11_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}