- claim_text
In mouse V1 slices, optogenetic co-activation of layer 2/3 pyramidal neurons produces persistent increases in neuronal excitability (reduced spike threshold, increased input resistance) that, more than synaptic plasticity, mediate ensemble formation.
- raw_fields
{
"n": null,
"doi": "10.7554/elife.77470",
"claim": "In mouse V1 slices, optogenetic co-activation of layer 2/3 pyramidal neurons produces persistent increases in neuronal excitability (reduced spike threshold, increased input resistance) that, more than synaptic plasticity, mediate ensemble formation.",
"cite_key": "AlejandreGarcia2022",
"evidence": "Whole-cell + perforated-patch paired recordings in acute V1 slices after optogenetic ensemble induction; pharmacological reversal by blocking membrane-resistance changes.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "mouse V1 layer 2/3 pyramidal neurons (in vitro)",
"argument_role": "supporting",
"replication_status": "single_study",
"claim_source_sentence": "In addition, we observed unexpected strong and persistent increases in neuronal excitability after stimulation, with increases in membrane resistance and reductions in spike threshold.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-8acf0afd8926"
]
- evidence_refs
[
{
"ref": "paper:paper-8acf0afd8926"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}