Version history

{
  "scope": "human, marmoset, mouse primary motor cortex; >450,000 single nuclei",
  "claim_text": "High-throughput transcriptomic and epigenomic profiling of >450,000 single nuclei from human, marmoset and mouse primary motor cortex demonstrates a broadly conserved cellular makeup whose similarities mirror evolutionary distance, while many cell-type-specific specializations (proportions, expression, DNA methylation, chromatin state) and few conserved marker genes are species-dependent.",
  "raw_fields": {
    "n": 450000,
    "doi": "10.1038/s41586-021-03465-8",
    "claim": "High-throughput transcriptomic and epigenomic profiling of >450,000 single nuclei from human, marmoset and mouse primary motor cortex demonstrates a broadly conserved cellular makeup whose similarities mirror evolutionary distance, while many cell-type-specific specializations (proportions, expression, DNA methylation, chromatin state) and few conserved marker genes are species-dependent.",
    "cite_key": "Bakken2021",
    "evidence": "Cross-species snRNA-seq plus snmC-seq and ATAC-seq of primary motor cortex (M1) generated a consensus cell-type taxonomy revealing conservation that scales with phylogenetic distance and identifying species-specific gene-regulatory specializations.",
    "effect_size": ">450,000 single nuclei profiled across human, marmoset, mouse",
    "text_access": "fulltext",
    "study_system": "human, marmoset, mouse primary motor cortex; >450,000 single nuclei",
    "source_cluster_id": "cluster_14",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Here, using high-throughput transcriptomic and epigenomic profiling of more than 450,000 single nuclei in humans, marmoset monkeys and mice, we demonstrate a broadly conserved cellular makeup of this region, with similarities that mirror evolutionary distance and are consistent between the transcriptome and epigenome.",
    "replication_evidence_dois": [
      "10.1038/s41586-019-1506-7",
      "10.1126/science.ade9516"
    ],
    "effect_size_source_sentence": "Here, using high-throughput transcriptomic and epigenomic profiling of more than 450,000 single nuclei in humans, marmoset monkeys and mice, we demonstrate a broadly conserved cellular makeup of this region, with similarities that mirror evolutionary distance and are consistent between the transcriptome and epigenome."
  },
  "section_id": "section_15",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_15_evidence_package.json",
  "effect_size": ">450,000 single nuclei profiled across human, marmoset, mouse",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-15",
  "source_kind": "review_finding",
  "source_path": "evidence/section_15_evidence_package.json",
  "source_refs": [
    "paper:paper-pm-34616062"
  ],
  "source_span": "Here, using high-throughput transcriptomic and epigenomic profiling of more than 450,000 single nuclei in humans, marmoset monkeys and mice, we demonstrate a broadly conserved cellular makeup of this region, with similarities that mirror evolutionary distance and are consistent between the transcriptome and epigenome.",
  "study_system": "human, marmoset, mouse primary motor cortex; >450,000 single nuclei",
  "evidence_refs": [
    {
      "ref": "paper:paper-pm-34616062"
    }
  ],
  "section_title": "Species Differences and Evolutionary Scaling of Loop Architecture",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Cross-species snRNA-seq plus snmC-seq and ATAC-seq of primary motor cortex (M1) generated a consensus cell-type taxonomy revealing conservation that scales with phylogenetic distance and identifying species-specific gene-regulatory specializations.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-15",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_15_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}