- claim_text
Multi-platform single-cell transcriptomics of the mouse primary motor cortex (6,160 SMART-seq cells, 280,327 MERFISH cells and 94,162 10x Genomics cells) reveals isoform-level cell-type specificity, including isoform shifts between cell types that are masked in gene-level analysis.
- raw_fields
{
"n": "6,160 SMART-seq + 280,327 MERFISH + 94,162 10x cells",
"doi": "10.1038/s41586-021-03969-3",
"claim": "Multi-platform single-cell transcriptomics of the mouse primary motor cortex (6,160 SMART-seq cells, 280,327 MERFISH cells and 94,162 10x Genomics cells) reveals isoform-level cell-type specificity, including isoform shifts between cell types that are masked in gene-level analysis.",
"cite_key": "Booeshaghi2021",
"evidence": "Full-length SMART-seq, MERFISH and 10x Genomics single-cell RNA-seq integrated across mouse M1 (BICCN).",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "mouse primary motor cortex, multi-platform single-cell transcriptomics",
"argument_role": "supporting",
"replication_status": "replication_unknown",
"claim_source_sentence": "we find examples of isoform specificity in cell types-including isoform shifts between cell types that are masked in gene-level analysis-as well as examples of transcriptional regulation. Additionally, we show that isoform specificity helps to refine cell types.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-9443e876ca93"
]
- source_span
we find examples of isoform specificity in cell types-including isoform shifts between cell types that are masked in gene-level analysis-as well as examples of transcriptional regulation. Additionally, we show that isoform specificity helps to refine cell types.
- evidence_refs
[
{
"ref": "paper:paper-9443e876ca93"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}