Compared with conventional 130 Hz STN-DBS, 60 Hz stimulation reduced laryngeal…

{
  "n": 7,
  "doi": "10.1212/wnl.0000000000001184",
  "claim": "Compared with conventional 130 Hz STN-DBS, 60 Hz stimulation reduced laryngeal aspiration frequency by 57% and perceived swallowing difficulty by 80%, with parallel improvement in freezing of gait.",
  "cite_key": "Xie2015",
  "evidence": "Randomized, double-blinded MBS swallowing assessment under 130 Hz, 60 Hz, and OFF in PD patients with persistent FOG, with 6-week chronic 60 Hz follow-up.",
  "effect_size": "57% aspiration reduction; 80% swallowing-difficulty reduction",
  "text_access": "fulltext",
  "study_system": "PD patients with bilateral STN-DBS and persistent freezing of gait (n=7)",
  "source_cluster_id": "cluster_13",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "We found that the low-stimulation\nfrequency of DBS at 60 Hz improved swallowing\nfunction compared with 130 Hz, by both the\nobjective MBS study (significantly decreasing\naspiration frequency by 57%) and the subjective\nquestionnaire (significantly decreasing swallowing\ndifficulty by 80%), a conclusion of significant\nclinical impact.",
  "replication_evidence_dois": [
    "10.1186/s40035-017-0083-7",
    "10.1002/mds.26837"
  ],
  "effect_size_source_sentence": "We found that the low-stimulation\nfrequency of DBS at 60 Hz improved swallowing\nfunction compared with 130 Hz, by both the\nobjective MBS study (significantly decreasing\naspiration frequency by 57%) and the subjective\nquestionnaire (significantly decreasing swallowing\ndifficulty by 80%), a conclusion of significant\nclinical impact."
}

[
  "paper:paper-c2d23dd91813"
]

We found that the low-stimulation frequency of DBS at 60 Hz improved swallowing function compared with 130 Hz, by both the objective MBS study (significantly decreasing aspiration frequency by 57%) and the subjective questionnaire (significantly decreasing swallowing difficulty by 80%), a conclusion of significant clinical impact.

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