Version history

{
  "scope": "mouse barrel cortex in vivo during active whisking; L2/3 cell-type-specific optogenetics",
  "claim_text": "During active sensing in mouse barrel cortex, optogenetic activation of L2/3 predominantly suppresses spontaneous L5 activity and deactivation of L2/3 facilitates L5 touch responses — opposite signs to the textbook feedforward-excitation account.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.1459-18.2018",
    "claim": "During active sensing in mouse barrel cortex, optogenetic activation of L2/3 predominantly suppresses spontaneous L5 activity and deactivation of L2/3 facilitates L5 touch responses — opposite signs to the textbook feedforward-excitation account.",
    "cite_key": "Pluta2019",
    "evidence": "Cell-type-specific optogenetic L2/3 manipulation in actively sensing mice; L5 single-unit recordings.",
    "effect_size": "Net L2/3→L5 suppressive effect during active sensation; somatostatin interneuron deactivation eliminates effect.",
    "text_access": "abstract_only",
    "study_system": "mouse barrel cortex in vivo during active whisking; L2/3 cell-type-specific optogenetics",
    "argument_role": "supporting",
    "replication_status": "contested",
    "claim_source_sentence": "Contrary to standard models, activating L2/3 predominantly suppressed spontaneous activity in L5, whereas deactivating L2/3 mainly facilitated touch responses in L5. Somatostatin interneurons are likely important to this suppression because their optogenetic deactivation significantly altered the functional impact of L2/3 onto L5.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1016/j.celrep.2018.08.038"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "Net L2/3→L5 suppressive effect during active sensation; somatostatin interneuron deactivation eliminates effect.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-ec77beb36424"
  ],
  "source_span": "Contrary to standard models, activating L2/3 predominantly suppressed spontaneous activity in L5, whereas deactivating L2/3 mainly facilitated touch responses in L5. Somatostatin interneurons are likely important to this suppression because their optogenetic deactivation significantly altered the functional impact of L2/3 onto L5.",
  "study_system": "mouse barrel cortex in vivo during active whisking; L2/3 cell-type-specific optogenetics",
  "evidence_refs": [
    {
      "ref": "paper:paper-ec77beb36424"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Cell-type-specific optogenetic L2/3 manipulation in actively sensing mice; L5 single-unit recordings.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "contested",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}