During active sensing in mouse barrel cortex, optogenetic activation of L2/3 pr…

During active sensing in mouse barrel cortex, optogenetic activation of L2/3 predominantly suppresses spontaneous L5 activity and deactivation of L2/3 facilitates L5 touch responses — opposite signs to the textbook feedforward-excitation account.

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  "n": 0,
  "doi": "10.1523/jneurosci.1459-18.2018",
  "claim": "During active sensing in mouse barrel cortex, optogenetic activation of L2/3 predominantly suppresses spontaneous L5 activity and deactivation of L2/3 facilitates L5 touch responses — opposite signs to the textbook feedforward-excitation account.",
  "cite_key": "Pluta2019",
  "evidence": "Cell-type-specific optogenetic L2/3 manipulation in actively sensing mice; L5 single-unit recordings.",
  "effect_size": "Net L2/3→L5 suppressive effect during active sensation; somatostatin interneuron deactivation eliminates effect.",
  "text_access": "abstract_only",
  "study_system": "mouse barrel cortex in vivo during active whisking; L2/3 cell-type-specific optogenetics",
  "argument_role": "supporting",
  "replication_status": "contested",
  "claim_source_sentence": "Contrary to standard models, activating L2/3 predominantly suppressed spontaneous activity in L5, whereas deactivating L2/3 mainly facilitated touch responses in L5. Somatostatin interneurons are likely important to this suppression because their optogenetic deactivation significantly altered the functional impact of L2/3 onto L5.",
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  "replication_evidence_dois": [
    "10.1016/j.celrep.2018.08.038"
  ],
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Contrary to standard models, activating L2/3 predominantly suppressed spontaneous activity in L5, whereas deactivating L2/3 mainly facilitated touch responses in L5. Somatostatin interneurons are likely important to this suppression because their optogenetic deactivation significantly altered the functional impact of L2/3 onto L5.

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