Single-nucleus RNA sequencing of the human middle temporal gyrus identified a h…

Single-nucleus RNA sequencing of the human middle temporal gyrus identified a highly diverse set of excitatory and inhibitory neuron types whose homologs are surprisingly well conserved with mouse cortex, but homologous types differ in proportions, laminar distributions, gene expression and morphology.

{
  "n": 0,
  "doi": "10.1038/s41586-019-1506-7",
  "claim": "Single-nucleus RNA sequencing of the human middle temporal gyrus identified a highly diverse set of excitatory and inhibitory neuron types whose homologs are surprisingly well conserved with mouse cortex, but homologous types differ in proportions, laminar distributions, gene expression and morphology.",
  "cite_key": "Hodge2019",
  "evidence": "snRNA-seq of human middle temporal gyrus compared to similar mouse cortex datasets identified well-conserved cell-type taxonomy with extensive species-specific divergence in expression and morphology.",
  "effect_size": "extensive divergence in proportions, laminar distributions, gene expression and morphology between homologous human and mouse cell types",
  "text_access": "fulltext",
  "study_system": "human middle temporal gyrus and mouse cortex; snRNA-seq",
  "source_cluster_id": "cluster_14",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Despite this general conservation, we also found extensive differences between homologous human and mouse cell types, including marked alterations in proportions, laminar distributions, gene expression and morphology.",
  "replication_evidence_dois": [
    "10.1038/s41586-021-03465-8",
    "10.1126/science.ade9516"
  ],
  "effect_size_source_sentence": "Despite this general conservation, we also found extensive differences between homologous human and mouse cell types, including marked alterations in proportions, laminar distributions, gene expression and morphology."
}

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