Version history

{
  "scope": "human and mouse cortical L1 Patch-seq cross-species",
  "claim_text": "In contrast to mouse, where Vip+ L1 interneurons localize to deeper L1, the equivalent VIP transcriptomic types in human cortex spread across L1, indicating species divergence in laminar position of L1-VIP cells that constrains cross-species comparisons of L1 VIP intrinsic-ephys recordings.",
  "raw_fields": {
    "n": null,
    "doi": "10.1126/science.adf0805",
    "claim": "In contrast to mouse, where Vip+ L1 interneurons localize to deeper L1, the equivalent VIP transcriptomic types in human cortex spread across L1, indicating species divergence in laminar position of L1-VIP cells that constrains cross-species comparisons of L1 VIP intrinsic-ephys recordings.",
    "title": null,
    "cite_key": "Chartrand2023",
    "evidence": "Patch-seq atlas of L1 GABAergic interneurons in human (n=323) and mouse (n=440) cortex, with cross-species transcriptomic alignment and morphology",
    "effect_size": "qualitative — VIP L1 types occupy deeper L1 in mouse, broader L1 distribution in human",
    "text_access": "fulltext",
    "study_system": "human and mouse cortical L1 Patch-seq cross-species",
    "_source_cluster": "cluster_04_intrinsic_electrophysiology",
    "replication_status": "replicated",
    "_source_cluster_index": 14,
    "claim_source_sentence": "Similarly, given the sublaminar selectivity of thalamic projections to Vip + versus Ndnf + cells in mouse L1 ( 56 ), the human L1 VIP types which are located in deeper layers in mouse may be especially relevant to thalamocortical microcircuit structure.",
    "replication_evidence_dois": [
      "10.1126/science.adf6484",
      "10.1038/s41586-021-03465-8"
    ],
    "effect_size_source_sentence": "Similarly, given the sublaminar selectivity of thalamic projections to Vip + versus Ndnf + cells in mouse L1 ( 56 ), the human L1 VIP types which are located in deeper layers in mouse may be especially relevant to thalamocortical microcircuit structure."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "effect_size": "qualitative — VIP L1 types occupy deeper L1 in mouse, broader L1 distribution in human",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-86dac47be132"
  ],
  "source_span": "Similarly, given the sublaminar selectivity of thalamic projections to Vip + versus Ndnf + cells in mouse L1 ( 56 ), the human L1 VIP types which are located in deeper layers in mouse may be especially relevant to thalamocortical microcircuit structure.",
  "study_system": "human and mouse cortical L1 Patch-seq cross-species",
  "evidence_refs": [
    {
      "ref": "paper:paper-86dac47be132"
    }
  ],
  "section_title": "Intrinsic Electrophysiology",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Patch-seq atlas of L1 GABAergic interneurons in human (n=323) and mouse (n=440) cortex, with cross-species transcriptomic alignment and morphology",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}