- claim_text
In contrast to mouse, where Vip+ L1 interneurons localize to deeper L1, the equivalent VIP transcriptomic types in human cortex spread across L1, indicating species divergence in laminar position of L1-VIP cells that constrains cross-species comparisons of L1 VIP intrinsic-ephys recordings.
- raw_fields
{
"n": null,
"doi": "10.1126/science.adf0805",
"claim": "In contrast to mouse, where Vip+ L1 interneurons localize to deeper L1, the equivalent VIP transcriptomic types in human cortex spread across L1, indicating species divergence in laminar position of L1-VIP cells that constrains cross-species comparisons of L1 VIP intrinsic-ephys recordings.",
"title": null,
"cite_key": "Chartrand2023",
"evidence": "Patch-seq atlas of L1 GABAergic interneurons in human (n=323) and mouse (n=440) cortex, with cross-species transcriptomic alignment and morphology",
"effect_size": "qualitative — VIP L1 types occupy deeper L1 in mouse, broader L1 distribution in human",
"text_access": "fulltext",
"study_system": "human and mouse cortical L1 Patch-seq cross-species",
"_source_cluster": "cluster_04_intrinsic_electrophysiology",
"replication_status": "replicated",
"_source_cluster_index": 14,
"claim_source_sentence": "Similarly, given the sublaminar selectivity of thalamic projections to Vip + versus Ndnf + cells in mouse L1 ( 56 ), the human L1 VIP types which are located in deeper layers in mouse may be especially relevant to thalamocortical microcircuit structure.",
"replication_evidence_dois": [
"10.1126/science.adf6484",
"10.1038/s41586-021-03465-8"
],
"effect_size_source_sentence": "Similarly, given the sublaminar selectivity of thalamic projections to Vip + versus Ndnf + cells in mouse L1 ( 56 ), the human L1 VIP types which are located in deeper layers in mouse may be especially relevant to thalamocortical microcircuit structure."
}- source_refs
[
"paper:paper-86dac47be132"
]
- source_span
Similarly, given the sublaminar selectivity of thalamic projections to Vip + versus Ndnf + cells in mouse L1 ( 56 ), the human L1 VIP types which are located in deeper layers in mouse may be especially relevant to thalamocortical microcircuit structure.
- evidence_refs
[
{
"ref": "paper:paper-86dac47be132"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}