- claim_text
In mouse forelimb motor cortex (M1), L6 corticothalamic neurons show strong reciprocal connections with other CT cells and with IT cells, but strikingly little excitatory connectivity with PT neurons — meaning the three projection classes do not all interconnect symmetrically in motor cortex.
- raw_fields
{
"n": null,
"doi": "10.1523/jneurosci.4023-14.2015",
"claim": "In mouse forelimb motor cortex (M1), L6 corticothalamic neurons show strong reciprocal connections with other CT cells and with IT cells, but strikingly little excitatory connectivity with PT neurons — meaning the three projection classes do not all interconnect symmetrically in motor cortex.",
"cite_key": "Yamawaki2015",
"evidence": "Cre-targeted CRACM and paired recordings among CT, IT, and PT projection neurons in mouse M1 slices.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "mouse forelimb motor cortex (M1) layer 6 CT and layer 5 IT/PT, in vitro slice",
"argument_role": "supporting",
"replication_status": "replication_unknown",
"claim_source_sentence": "Stimulating and recording from CT, intratelencephalic (IT), and pyramidal tract (PT) projection neurons, we found strong CT↔ CT and CT↔ IT connections; however, CT→IT connections were limited to IT neurons in layer 6, not 5B. There was strikingly little CT↔ PT excitatory connectivity.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-77ff3f69a352"
]
- source_span
Stimulating and recording from CT, intratelencephalic (IT), and pyramidal tract (PT) projection neurons, we found strong CT↔ CT and CT↔ IT connections; however, CT→IT connections were limited to IT neurons in layer 6, not 5B. There was strikingly little CT↔ PT excitatory connectivity.
- evidence_refs
[
{
"ref": "paper:paper-77ff3f69a352"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}